Kelkka, Tiina
Tyster, Mikko
Lundgren, Sofie http://orcid.org/0000-0003-3146-9816
Feng, Xingmin
Kerr, Cassandra
Hosokawa, Kohei http://orcid.org/0000-0002-3423-1523
Huuhtanen, Jani http://orcid.org/0000-0003-2750-4033
Keränen, Mikko
Patel, Bhavisha
Kawakami, Toru http://orcid.org/0000-0003-0178-5332
Maeda, Yuka
Nieminen, Otso
Kasanen, Tiina
Aronen, Pasi
Yadav, Bhagwan
Rajala, Hanna
Nakazawa, Hideyuki
Jaatinen, Taina
Hellström-Lindberg, Eva http://orcid.org/0000-0002-7839-3743
Ogawa, Seishi
Ishida, Fumihiro http://orcid.org/0000-0002-0525-7636
Nishikawa, Hiroyoshi
Nakao, Shinji http://orcid.org/0000-0002-9674-624X
Maciejewski, Jaroslaw http://orcid.org/0000-0002-6837-4346
Young, Neal S.
Mustjoki, Satu http://orcid.org/0000-0002-0816-8241
Article History
Received: 13 May 2022
Revised: 6 July 2022
Accepted: 11 July 2022
First Online: 5 August 2022
Competing interests
: SM has received honoraria and research funding from Novartis, Pfizer, and Bristol-Myers Squibb (not related to this study). SN has received honoraria from Novartis, Kyowa-Kirin, and Symbio (not related to this study). The remaining authors declare no competing interests.
: Plasma samples from patients and healthy controls were collected according to the institutional ethics approvals (Helsinki: 303/12/03/01/2011, 181/13/03/01/12, Cleveland, USA: National Heart, Lung and Blood Institute IRB 5024 CR, Kanazawa, Japan: Kanazawa 2018/4/25 and Shinshu, Japan: Shinshu IRB 581) after informed consent. The principles of the Declaration of Helsinki were followed. Biobank samples were obtained from Helsinki Biobank and from The Finnish Hematology Registry and Clinical Biobank (FHRB).