Received: 8 May 2018
Revised: 31 July 2018
Accepted: 26 September 2018
First Online: 23 October 2018
Compliance with ethical standards
: HC had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. HC, LI, and ED are partially supported by a research contract from Janssen Research, LLC. QSL is an investigator at Janssen Research, LLC. The remaining authors have no conflicts of interest relevant to the content of this manuscript, including no financial interest, relationships, or affiliations.