Received: 23 March 2022
Revised: 24 August 2022
Accepted: 31 August 2022
First Online: 15 September 2022
: The authors declare no competing interests.
: Tumor and adjacent ESCC tissues were obtained from ESCC cancer patients who underwent surgery at Henan Cancer Hospital. The experimental protocol was approved by the ethics committee of Zhengzhou University School of Medicine, Henan Cancer Hospital (No. 2017407). No patient received chemotherapy or radiotherapy prior to surgery. Animal experimental protocol was approved by the ethics committee of China-US (Henan) Hormel Cancer Institute (No. CUHCI2019003).