Tombal, Bertrand F.
Freedland, Stephen J.
Armstrong, Andrew J. http://orcid.org/0000-0001-7012-1754
Beer, Tomasz M. http://orcid.org/0000-0001-5600-9993
Stenzl, Arnulf
Sternberg, Cora N.
Hussain, Maha http://orcid.org/0000-0003-0380-9465
Ganguli, Arijit
Ramaswamy, Krishnan http://orcid.org/0000-0003-0890-0268
Bhadauria, Hemant
Ivanescu, Cristina
Turnbull, James
Holmstrom, Stefan
Saad, Fred http://orcid.org/0000-0003-2986-5617
Funding for this research was provided by:
This study, in addition to the four studies informing the analyses reported in the manuscript, was funded by Astellas Pharma Inc. and Pfizer Inc., the co-developers of enzalutamide.
This study, in addition to the four studies informing the analyses reported in the manuscript, was funded by Astellas Pharma Inc. and Pfizer Inc, the co-developers of enzalutamide.
Astellas Pharma US
Pfizer
Article History
Received: 30 April 2021
Revised: 12 August 2021
Accepted: 19 August 2021
First Online: 13 September 2021
Competing interests
: BFT has received grants or contracts, consulting fees, and payment or honoraria for lectures, presentations, speaker bureaus, publication writing, or educational events from Amgen, Astellas, Bayer, Janssen, Myovant, Novartis (Advanced Accelerator Applications), and Sanofi and payment for expert testimony from Tookad. SJF has received consulting fees from Astellas, AstraZeneca, Bayer, Clovis, Janssen, Merck, Myovant, Pfizer, and Sanofi and payment for lectures, presentations, speaker bureaus, publication writing, or education events from AstraZeneca and Sanofi. AJA has received research funding from AstraZeneca, Bayer, Bristol Myers Squibb, Clovis, Constellation, Dendreon, Janssen, Medivation, Merck, Novartis, Pfizer, Roche/Genentech, and Sanofi, consulting fees from Astellas, AstraZeneca, Bayer, Dendreon, Janssen, Medivation, Merck, Novartis, Pfizer, and Sanofi, payment or honoraria for lectures, presentations, speaker bureaus, publication writing, or educational events from Bayer and Dendreon, and support for attending meetings and/or travel from Bayer, Dendreon, and Janssen. TMB has received consulting fees from Arvinas, Astellas, AstraZeneca, Bayer, Bristol Myers Squibb, Clovis, Constellation, GlaxoSmithKline, Grail, Janssen, Merck, Myovant, Novartis, Pfizer, Sanofi, and Tolero and owns stock or stock options in Arvinas and Salarius; his institution has received grants or contracts from Alliance Foundation Trials, Bayer, Boehringer Ingelheim, Corcept, Endocyte/Advanced Accelerator Applications, Freenome, Grail, Harpoon, Janssen, Medivation, Sotio, Theraclone Sciences/OncoResponse, and Zenith Epigenetics. AS has received research grants from Amgen, Immatics Biotechnologies GmbH, Karl Storz AG, and Novartis AG, consulting fees from Alere, Ipsen, Janssen, and Roche, payment or honoraria as a speaker from Amgen, Astellas, AstraZeneca, CureVac, Ipsen, Janssen, and Sanofi Aventis and for participating in advisory board meetings from Alere, Bristol Myers Squibb, Ferring, Ipsen, Janssen, Roche, Stebabiotech, and Synergo, and served as an investigator in clinical trials sponsored by Bayer AG, Cepheid, CureVac, GenomeDx Biosciences, Immatics Biotechnologies GmbH, Johnson & Johnson, and Roche. CNS has received honoraria for lectures, presentations, speaker bureaus, publication writing, or educational events from Astellas, AstraZeneca, Bristol Myers Squibb, CCO Clinical, Foundation Medicine, Immunomedics (now Gilead), Incyte, Janssen, Medscape, Merck, MSD, NCI, Pfizer, Roche-Genentech, Sanofi-Genzyme, and UroToday and payment or honoraria for participating in advisory board meetings from Impact, NCI, and NeoTx. MH has received contracts for clinical trials from Arvinas, AstraZeneca, Bayer, Genentech, and Pfizer and honoraria for lectures at symposiums from Astellas, AstraZeneca, Merck, and Sanofi/Genzyme and for participating in advisory board meetings from Bayer, Bristol Myers Squibb, Daiichi Sankyo, Genentech, and Janssen. AG, HB, and SH are employees of Astellas. KR is an employee of Pfizer. CI and JT are employees of IQVIA, which received professional service fees from Astellas for conducting the analyses presented here. FS has received consulting fees and payments or honoraria for lectures, presentations, speaker bureaus, publication writing, or educational events from Amgen, Astellas, AstraZeneca, Bayer, Bristol Myers Squibb, Janssen, Merck, Myovant, Pfizer, and Sanofi; his institution has received grants or contracts from Astellas, AstraZeneca, Bayer, Bristol Myers Squibb, Janssen, Merck, Myovant, Pfizer, and Sanofi. In addition, all authors received support from Astellas, in the form of study funding, IQVIA, in the form of study analysis and medical writing, and Complete HealthVizion, in the form of editing of the manuscript.
: All four studies were approved by the local Ethics Committees and conducted in accordance with the principles of the Declaration of Helsinki. All patients gave their signed informed consent before blood collection and data analysis.