Le, Trang T.
Savitz, Jonathan
Suzuki, Hideo
Misaki, Masaya
Teague, T. Kent
White, Bill C. http://orcid.org/0000-0002-0684-5210
Marino, Julie H.
Wiley, Graham
Gaffney, Patrick M.
Drevets, Wayne C.
McKinney, Brett A.
Bodurka, Jerzy
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH098099)
Article History
Received: 27 November 2017
Revised: 21 June 2018
Accepted: 14 July 2018
First Online: 5 September 2018
Change Date: 9 August 2020
Change Type: Update
Change Details: This Article has been corrected to clear up scientific details (see the authors’ summary below).
Change Details: “Our analysis used stranded RNA-Seq preprocessing where the forward direction was used for the second fast sequence files. This stranded preprocessing enriches for antisense non-coding RNA, sometimes called Natural Antisense Transcripts (NATs). These NATs are labeled with AS1 (for antisense) appended to their gene symbols, and they are known to recruit epigenetic machinery and other mechanisms to regulate coding RNA (mRNA/genes). In addition to NATs, stranded preprocessing enriches for protein coding genes that can be transcribed in the antisense direction, which occurs for a significant proportion of mammalian genes (i.e., protein coding). Thus, the replicated module (M5) contains genes that are enriched for antisense expression of protein coding genes and expression of NATs that regulate partner coding genes through an antisense mechanism. We include the RNA-Seq data preprocessed for both antisense RNA and sense RNA gene expression in the github repository (https://github.com/insilico/DepressionGeneModules).”.
Change Date: 12 August 2020
Change Type: Correction
Change Details: A Correction to this paper has been published:
Change Details: https://doi.org/10.1038/s41398-020-00968-2
Conflict of interest
: W.C.D. is an employee of Janssen Research & Development, LLC, of Johnson & Johnson, Inc. The remaining authors declare that they have no conflict of interests.