Pratz, Keith W. http://orcid.org/0000-0002-1284-8266
Panayiotidis, Panayiotis
Recher, Christian http://orcid.org/0000-0002-3332-4525
Wei, Xudong
Jonas, Brian A. http://orcid.org/0000-0002-4921-5809
Montesinos, Pau http://orcid.org/0000-0002-3275-5593
Ivanov, Vladimir
Schuh, Andre C.
DiNardo, Courtney D. http://orcid.org/0000-0001-9003-0390
Novak, Jan
Pejsa, Vlatko
Stevens, Don
Yeh, Su-Peng
Kim, Inho
Turgut, Mehmet
Fracchiolla, Nicola
Yamamoto, Kazuhito http://orcid.org/0000-0002-8588-8955
Ofran, Yishai
Wei, Andrew H.
Bui, Cat N.
Benjamin, Katy
Kamalakar, Rajesh
Potluri, Jalaja
Mendes, Wellington http://orcid.org/0000-0002-0733-8456
Devine, Jacob
Fiedler, Walter
Funding for this research was provided by:
AbbVie (NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352, NCT03069352)
Genentech (NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523, NCT02993523)
Article History
Received: 21 December 2021
Revised: 24 March 2022
Accepted: 1 April 2022
First Online: 20 April 2022
Competing interests
: KWP: grant support and advisory board fees from AbbVie, Astellas, Agios, Bristol Myers Squibb, Celgene, Daiichi Sankyo, Jazz Pharmaceuticals, Servier, and Millennium; grant support from Astellas, Boston BioMedical, Celgene, Jazz Pharmaceuticals. PP: grant and research support from AbbVie, Roche, Novartis, and Genesis; honoraria from AbbVie, Janssen, Roche, Novartis, Gilead, and GCR: Research grants from Abbvie, Amgen, Novartis, Celgene, Jazz Pharmaceuticals, Agios, Chugai, MaatPharma, Astellas, Iqvia, Roche and DS; an advisory role for Abbvie, Janssen, Jazz Pharmaceuticals, Novartis, Celgene, Otsuka, Astellas, Daiichi-Sankyo, Macrogenics, Roche, Takeda, and Pfizer. BAJ: consultant/advisory role for AbbVie, BMS, Genentech, Gilead, GlycoMimetics, Jazz, Pfizer, Servier, Takeda, Tolero, and Treadwell; protocol steering committee for GlycoMimetics; data monitoring committee for Gilead; travel reimbursement from AbbVie; research funding to his institution from 47, AbbVie, Accelerated Medical Diagnostics, Amgen, AROG, BMS, Celgene, Daiichi Sankyo, F. Hoffmann-La Roche, Forma, Genentech/Roche, Gilead, GlycoMimetics, Hanmi, Immune-Onc, Incyte, Jazz, Loxo, LP Therapeutics, Pfizer, Pharmacyclics, Sigma Tau, and Treadwell. PM: advisor/speaker/research support from AbbVie, Janssen, Novartis, Pfizer, and Teva; advisor/speaker/consultant/research support for Astellas, Celgene, and Daiichi-Sankyo; consultant for Agios, Tolero Pharmaceuticals, Glycomimetics, and Forma Therapeutics; advisor/speaker for Incyte and Sanofi; advisor/research support for Karyopharm. ACS: received research funding from AbbVie, Agios, Amgen, BMS/Celgene, Glycomimetics, Pfizer, and Novartis; advisory board member for AbbVie, Agios, Amgen, Astellas, BMS/Celgene, Taiho, and Teva. CD: received research funding from AbbVie/Genentech, Agios, Celgene, Daiichi Sankyo, Millennium, and Novartis and served as consultant for Agios; advisory board member for AbbVie, Agios, Bayer, Celgene, Karyopharm, and Medimmune. JN: consultant/advisor for Novartis, Roche, Pfizer, Amgen, Takeda, and Astellas; received travel expenses from Amgen and Janssen. VP: received advisory board fees, lecture fees, and consulting fees from AbbVie, Janssen, and Amgen; advisory board fees and lecture fees from Takeda, Roche, Pliva, and Sandoz; lecture fees from Alvogen and Oktal Pharma. S-PY: advisory board member for AbbVie, Amgen, Janssen, Astellas, Astex, and Takeda. NF: honoraria from Amgen, Pfizer, Gilead, and AbbVie; speakers bureau for Amgen, Pfizer, and Gilead; advisory board for Amgen, Pfizer, Gilead, and AbbVie; travel support from Amgen, Pfizer, Gilead, and AbbVie. KY: consultancy (includes expert testimony) for AbbVie, AstraZeneca, Celgene, Chugai, Daiichi Sankyo, Eisai, HUYA, Meiji Seika Pharma, MSD, Mundipharma, Ono, Otsuka, Stemline Therapeutics and Takeda; research funding from AbbVie, Astra-Zeneca, Bayer, Celgene, Chugai, Eisai, Gilead Sciences, IQIVA/Incyte, MSD, Mundipharma, Nippon Shinyaku, Novartis, Ono, Otsuka, Solasia Pharma, SymBio, Takeda, Yakult and Zenyaku; honoraria from AbbVie, Bristol-Myers Squibb, Celgene, Chugai, Eisai, IQIVA/HUYA, Janssen, Kyowa Kirin, Meiji Seika Pharma, Mochida, MSD, Mundipharma, Nippon Shinyaku, Novartis, Ono, Otsuka, Pfizer, Sanofi, Sumitomo Dainippon, and Takeda. YO: has served on advisory boards for AbbVie. AHW: served in an advisory role for Astellas, AbbVie/Genentech, Amgen, Celgene/BMS, Novartis, Astra Zeneca, Servier, Janssen, MacroGenics, Pfizer, Gilead, and Syndax; received research funding from Astellas, Astex, AbbVie, Genentech, Amgen, Astra Zeneca, Celgene/BMS, Novartis, Servier, and Syndax; honoraria from Astellas, AbbVie, Genentech, Amgen, Astra Zeneca, Celgene/BMS, Novartis, Servier, Janssen, MacroGenics, Pfizer, Gilead, and Syndax; served as a consultant for: Astellas, Servier, Janssen, Gilead, and Syndax; is an employee of Walter and Eliza Hall Institute (WEHI) and is eligible for financial benefits associated with payments which WEHI receives in relation to venetoclax. WF: advisory and consulting role for Amgen; advisory role for ARIAD/Incyte, Novartis, Pfizer; Celgene, Morphosys, AbbVie, Jazz Pharmaceuticals, and Servier; royalties from Amgen; support for meeting attendance from Amgen, Gilead, Servier, Jazz Pharmaceuticals, and Daiichi Sankyo; research funding from Amgen and Pfizer. IK, XW, VI, DS, and MT: nothing to disclose. CNB, RK, JP, and WM: employees of AbbVie and may hold stock or stock options. KB is a former employee of AbbVie and may hold stock or stock options. JD: employee of Genentech and may hold stock in the company. Venetoclax is being developed in a collaboration between AbbVie and Genentech. AbbVie and Genentech funded NCT02993523 and AbbVie funded NCT03069352 and participated in the given study design, research, analysis, data collection, interpretation of data, reviewing, and approval of the publication. All authors had access to relevant data and participated in the drafting, review, and approval of this article. No honoraria or payments were made for authorship.