Loupakis, Fotios
Hurwitz, Herbert I.
Saltz, Leonard
Arnold, Dirk
Grothey, Axel
Nguyen, Quynh Lan
Osborne, Stuart
Talbot, Jonathan
Srock, Stefanie
Lenz, Heinz-Josef
Funding for this research was provided by:
F. Hoffmann-La Roche/Genentech
Article History
Received: 26 January 2018
Revised: 28 August 2018
Accepted: 24 September 2018
First Online: 29 November 2018
Competing interests
: F.L. served as a consultant/advisor for Roche, Amgen, and Bayer, and had travel, accommodations, and/or expenses paid for by Roche, Amgen, Merck Serono, and Bayer. H.I.H. is a current employee of Genentech/Roche and previously served on the advisory board of Genentech/Roche. L.S. received research funding from Taiho. D.A. received honoraria from, and served as a consultant or advisor for, BMS, Roche, Bayer, Merck, and EMD, and received research funding from BMS, Roche, Bayer, Merck, EMD, Incyte, and Taiho. Q.L.N., S.O., and J.T. are employees of Roche. S.S. is an employee of Roche and has a leadership role, owns stock, served as a consultant/advisor, received research funding, had travel/accommodations expenses paid, and had other relationships with Roche. H.-J.L. served on the advisory board for Bayer, Lilly, Merck, Roche, Sanofi, Servier, Sirtex, and Terumo; served as a lecturer for Bayer, Biocompatibles, Lilly, Merck, MSD, Roche, Sanofi, Servier, and Sirtex; and received research funding from Mologen, Roche, and Sanofi. A.G. declares no competing interests.
: This study was conducted in accordance with International Conference on Harmonisation Good Clinical Practice regulations and the Declaration of Helsinki. The informed consent document and protocol were reviewed and approved by the Independent Ethics Committees of each study centre. All patients provided written informed consent before enrolment.
: Qualified researchers may request access to individual patient level data through the clinical study data request platform (ExternalRef removed). Further details on Roche’s criteria for eligible studies are available here (ExternalRef removed). For further details on Roche’s Global Policy on the Sharing of Clinical Information and how to request access to related clinical study documents, see here (ExternalRef removed).
: This study was supported by F Hoffmann-La Roche/Genentech. LS was funded in part by P30-17 CA008748.