Funding for this research was provided by:
Cancer Research UK (FC001223)
Wellcome Trust (FC001223)
University of Louisville (20044)
RCUK | Medical Research Council (FC001223)
National Institute of Health, USA
Text and Data Mining valid from 2019-05-22
Received: 26 June 2018
Revised: 1 February 2019
Accepted: 7 March 2019
First Online: 22 May 2019
: T.W.-M.F., A.N.L., R.M.H. and M.B. II declare that they have filed a US patent application entitled “Methods for Detecting Cancer” (US20130109592). T.D.A. is a co-founder of Tradewind BioScience Inc. However, the company’s interest does not overlap with the work covered in the present manuscript.
: This work was supported in part by National Science Foundation EPSCoR infrastructure grants EPS-0447479 (to T.W.-M.F.); NIH grants 5P01CA163223 (to A.N.L and T.W.-M.F) 1R01CA118434-01A2, 1RO1CA101199-01, 3R01CA118434-02S1 and 1R01ES022191-01 (to T.W.-M. F.), and 1U24DK097215-01A1 (to R.M.H., T.W.M.F. and A.N.L.); the University of Louisville CTSPGP/ARRA grant 20044; the Kentucky Lung Cancer Research Program grants OGMB090354B1 and OGMB101380 (to T.W.-M.F. and A.N.L.). This work was also supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001223), the UK Medical Research Council (FC001223), and the Wellcome Trust (FC001223).
: The data sets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
: The study “Metabolomic Analysis of Tissue: A Translational Clinical Trial” was approved by the IRB committee of the University of Louisville (#523.05). Written informed consent was obtained from all subjects prior to inclusion in this study. The study was performed in accordance with the Declaration of Helsinki. The animal experiments were conducted with the approval of either the Institutional Animal Care and Use Committee (IACUC) of the University of California, San Francisco or in accordance with United Kingdom regulations under project license PPLs 80/2623 and P609116C5.