Funding for this research was provided by:
RCUK | Engineering and Physical Sciences Research Council (EP/N014499/1)
Received: 13 February 2019
Revised: 1 May 2019
Accepted: 10 May 2019
First Online: 11 June 2019
: The authors declare no competing interests.
: The subjects in this study were part of two large trials that were previously published. As such, ethical approval has been acquired and study performed in accordance with the Declaration of Helsinki, with all patients giving informed consent.
: S.B. and M.G.F. acknowledge support from the UK EPSRC grant EP/N014499/1.
: Not applicable
: All data remain the property of the sponsors of the trials from which they were extracted, as noted in the acknowledgments section.
: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).