Received: 26 March 2019
Revised: 1 July 2019
Accepted: 18 July 2019
First Online: 16 August 2019
Change Date: 14 January 2020
Change Type: Correction
Change Details: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
: R. Gillies has a sponsored research support from Helix Biopharma. The other authors declare no competing interests.
: All experiments were performed in accordance with Institutional Animal Care & Use Committee (IACUC) standards maintained by The University of South Florida (USF) and followed by Moffitt Cancer Center. USF affirms that respect for all forms of life is an inherent characteristic of biological and medical scientists who conduct research involving animals, that the respectful treatment, care and use of animals involved in research is an ethical and scientific necessity and that the use of animals in research and teaching contributes to the advancement of knowledge and the acquisition of understanding. Experiments reported in this study was performed under protocol “Causes and Consequences of Acid Tumor pH, number R-IS00000549, granted to R. Gillies”. The study involves analysing existing publicly available TCGA data sets, which does not require ethics approval.
: This work is partially funded by NIH grants R01CA077575 (to R. Gillies), U54CA193489 (to R. Gatenby, A.A.), U01CA151924 (to A.A.) and R00CA185325-02 (to B.R.). A.E. was partially funded by a fellowship awarded by Egyptian Ministry of High Education and Mansoura University. This work was supported by the Moffitt Cancer Center Flow Cytometry, Molecular Genomics, Analytic Microscopy and Tissue Core Facilities, all comprehensive cancer center facilities designated by the National Cancer Institute (P30CA076292).
: No individual person’s data in any form were used in this study.
: The authors declare that the main data supporting the findings of this study are available within the article and its InternalRef removed. Mathematical model code is available for access on github ExternalRef removed