Nanou, Afroditi
Miller, M. Craig
Zeune, Leonie L.
de Wit, Sanne
Punt, Cornelis J. A.
Groen, Harry J. M.
Hayes, Daniel F.
de Bono, Johann S.
Terstappen, Leon W. M. M.
Article History
Received: 19 September 2019
Revised: 17 December 2019
Accepted: 19 December 2019
First Online: 15 January 2020
Ethics approval and consent to participate
: All individuals provided written informed consent prior to participation in the trial protocols approved by institutional review boards at the participating centres of the studies.<sup>31–38</sup> The studies were performed in accordance with the Declaration of Helsinki.
: Not applicable.
: The data sets used and analysed during the current study are available from the corresponding author on reasonable request.
: D.F.H. reports research support from Menarini Silicon Biosystems (MSB), Merrimack, Eli Lilly, Puma Biotechnology, Pfizer and AstraZeneca. He is the named inventor of patent US 8,790,878 B2. D.H.F., which is licensed to MSB and from whom he receives royalties. He holds stock options from OncImmune LLC and InBiomotion, and he serves as a paid advisor for Cepheid, Freenome, CellWorks, Agendia and CVS Caremark. J.S.d.B. has served as a consultant for Astellas, AstraZeneca, Bayer, Daiichi, Genentech, GSK, Janssen, Merck Serono, MSD, Orion, Pfizer Oncology, Sanofi-Aventis, Menarini Silicon Biosystems and Taiho. L.W.M.M.T. is listed as an inventor on U.S. patents (No: 5,985,153; No: 5,993,665; No: 6,013,188; No: 6,136,182; No: 6,361,749; No: 6,365,362; No: 6,551,843 B1; No: 6,623,982 B1; No: 6,620,627 B1; No: 6,623,983 B1; No: 6,645,731 B2; No: 6,660,159 B1; No: 6,790,366 B2; No: 6,890,426 B2; No: 7,056,657 B2; No: 7,332,288 B2; 7,863,012 B2; No: 8,329,422 B2) related to the CellSearch system, the rights of which are assigned to Menarini Silicon Biosystems; he is the chairman of the department of Medical Cell BioPhysics at the University of Twente, which receives research funding related to the CellSearch system from Menarini Silicon Biosystems. The other authors declare no conflict of interest.
: This work was supported by NWO Applied and Engineering Science Cancer-ID project # 14190, EUFP7 CTCTrap project #305341 and the EU IMI CANCER-ID project # 115749–1. The de Bono laboratory is supported by Cancer Research UK, ECMC funding, Movember, Prostate Cancer UK and the Prostate Cancer Foundation.