Funding for this research was provided by:
NIHR Great Ormond Street Hospital Biomedical Research Centre NIHR Academic Clinical fellowship
Received: 8 June 2020
Revised: 24 July 2020
Accepted: 7 September 2020
First Online: 1 October 2020
Ethics approval and consent to participate
: The child’s legal guardian provided informed consent for participation in this REC-approved study (UK NHS National Research Ethics Service reference 16/EE/0394). All patient information has been anonymised for the purposes of this letter. The study was performed in accordance with the Declaration of Helsinki.
: Express consent has been given to publish the details of this case by the child’s legal guardian.
: Raw sequencing data pertaining to this case are available in EGA.
: Dr. Slater has advised Bayer on TRK inhibitors. The remaining authors declare no competing interests.
: S.B. and T.R.W.O. are funded by Wellcome. All research at Great Ormond Street Hospital NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR Great Ormond Street Hospital Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.