Cha, Pu-Hyeon
Hwang, Jeong-Ha
Kwak, Dong-Kyu
Koh, Eunjin
Kim, Kyung-Sup
Choi, Kang-Yell http://orcid.org/0000-0002-0952-3276
Funding for this research was provided by:
P-H Cha, J-H Hwang, and D-K Kwak were supported by a BK21 PLUS program.
National Research Foundation of Korea (2019R1A2C3002751, 2016R1A5A1004694)
Article History
Received: 24 February 2020
Revised: 25 August 2020
Accepted: 25 September 2020
First Online: 19 October 2020
Ethics approval and consent to participate
: All animal experiments were performed in accordance with Korean Food and Drug Administration guidelines. Protocols were reviewed and approved by the Institutional Review Board of Severance Hospital, Yonsei University College of Medicine.
: Not applicable.
: The datasets generated and/or analysed during the current study are available through Gene expression omnibus (GEO) or the corresponding references. Data of the microarray analysis: Gene Expression. Data of the microarray analysis on normal tissues and adenoma of small intestine tissues from WT and <i>Apc</i><sup><i>min/+</i></sup> mice are shown in Fig. InternalRef removed and Fig. InternalRef removed: ExternalRef removed. Data of the microarray analysis on human normal colon and CRC samples are shown in Fig. InternalRef removed: ExternalRef removed. Enrichment of glycolysis and glyconeogenesis in human tissues of normal mucosa and colorectal adenomas is shown in Fig. InternalRef removed (left panel): ExternalRef removed. Enrichment of glycolysis and glyconeogenesis in CRC patients with and without <i>APC</i> mutations is shown in Fig. InternalRef removed (right panel): ExternalRef removed. Gene expression of <i>LDHA, AXIN2</i> and <i>MYC</i> in human CRC samples harbouring WT and MT <i>APC</i> in Fig. InternalRef removed: ExternalRef removed.
: The authors declare no competing interests.
: This work was supported by the National Research Foundation (NRF) of Korea grant funded by the Korean Government (MSIP) (grant 2019R1A2C3002751 and 2016R1A5A1004694; to K-Y.C.). P-H.C., J-H.H. and D-K.K. were supported by a BK21 PLUS program.