Cheung, Vincent Ting Fung http://orcid.org/0000-0003-1715-2281
Gupta, Tarun
Olsson-Brown, Anna
Subramanian, Sreedhar
Sasson, Sarah Christina
Heseltine, Jonathan
Fryer, Eve
Collantes, Elena
Sacco, Joseph J.
Pirmohamed, Munir
Simmons, Alison
Klenerman, Paul
Tuthill, Mark
Protheroe, Andrew S.
Chitnis, Meenali
Fairfax, Benjamin Peter
Payne, Miranda Jane
Middleton, Mark Ross
Brain, Oliver
Funding for this research was provided by:
Norman Collisson Foundation
Lee Placito Fellowship
RCUK | Medical Research Council (MR/N025989/1)
Celgene
Wellcome Trust
Article History
Received: 19 December 2019
Revised: 6 April 2020
Accepted: 24 April 2020
First Online: 18 May 2020
Ethics approval and consent to participate
: This research forms part of the preliminary work for the ethics-approved PRedicting Immunotherapy Side Effects (PRISE) Study (London-Surrey Research Ethics Committee: REC18/LO/0412) and the ‘A Mechanistic Investigation into Drug and Chemical Induced Hypersensitivity Reactions (HYST)’ study (REC12/NW/0525). The patients who had endoscopy assessment in Oxford also consented to participation within the ‘Gastrointestinal Illness in Oxford: prospective cohort for outcomes, treatment, predictors and biobanking’ (16/YH/0247). Appropriate Caldicott approvals are in place. The study was performed in accordance with the Declaration of Helsinki.
: All patients starting immune checkpoint inhibitors gave written informed consent for their clinical data to be used for teaching and publications within the remit of the Oxford University Hospital Trust GI Biobank or the Clatterbridge Cancer Centre Biobank, which have been approved by institutional ethics committees.
: The authors confirm that the data supporting the findings of this study are available within the article and its supplementary materials. Supplementary information is available at the <i>British Journal of Cancer</i>’s website.
: V.T.F.C. has received speaker fees from Janssen. A.O.-B. is an MRC Clinical Training Fellow based at the University of Liverpool supported by the North West England Medical Research Council Fellowship Scheme in Clinical Pharmacology and Therapeutics, which is funded by the Medical Research Council, Roche Pharma, Eli Lilly and Company Limited, UCB Pharma, Novartis, the University of Liverpool and the University of Manchester. She has received honoraria for speaking at educational events from Roche Pharma, Bristol-Myers-Squibb (BMS) and MSD. She has received honoraria for attending BMS advisory boards. J.J.S. has received speaker fees from BMS and Pierre Fabre; acted as a consultant for BMS, MSD, Amgen, Delcath and Immunocore; and his institution has received research grants from BMS and AZ. M.P. is the director of the North West England Medical Research Council Fellowship Scheme in Clinical Pharmacology and Therapeutics. M.R.M. has acted as a consultant for Amgen, AstraZeneca, Bristol-Myers Squibb, Eisai, GlaxoSmithKline, Immunocore, Lilly, Merck, Millennium, Novartis, Physiomics, Rigontec, and Roche; his institution has received research grants from Abbvie, Amgen, AstraZeneca, Bristol-Myers Squibb, Clovis, Eisai, GlaxoSmithKline, Immunocore, Merck, Millennium, Novartis, Pfizer, Rigontec, Roche, and Vertex. O.B. has received speaker fees from BMS and has received a research grant from Celgene. M.T. has performed Advisory/Consultancy work for Pfizer, Novartis, Lilly, Janssen, Roche, Vaccitech, BMS, and has been a paid speaker for and received paid speaking engagements and education support from Novartis, Pfizer, Roche, Janssen, BMS, Genomic Health, Astellas, Esai, Everything Genetics. A.P. has received honoraria from Ipsen, Roche Bayer, Merck and BMC; and has received non-financial support from Ipsen and grants from Merck. The other authors have no conflicts of interest.
: The research was supported by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. V.T.F.C. is funded by grants from the Norman Collisson Foundation and Oxfordshire Health Services Research Committee (OHSRC), part of Oxford Hospitals Charity. T.G. is supported by a clinical training fellowship from the Lee Placito Fund. S.C.S. is funded by an Oxford-Celgene Postdoctoral Fellowship. B.P.F. is supported by a Wellcome Intermediate Clinical Fellowship (201488/Z/16/Z). A.O.-B. is supported by a Medical Research Council (MRC) Clinical Research Fellowship (MR/N025989/1). A.S. is supported by a Wellcome Investigator Award and UK Medical Research Council.