Martins, Filipe Correia
Couturier, Dominique-Laurent
Paterson, Anna
Karnezis, Anthony N.
Chow, Christine
Nazeran, Tayyebeh M.
Odunsi, Adekunle
Gentry-Maharaj, Aleksandra
Vrvilo, Aleksandra
Hein, Alexander
Talhouk, Aline
Osorio, Ana
Hartkopf, Andreas D.
Brooks-Wilson, Angela
DeFazio, Anna
Fischer, Anna
Hartmann, Arndt
Hernandez, Brenda Y.
McCauley, Bryan M.
Karpinskyj, Chloe
de Sousa, Christiani B.
Høgdall, Claus
Tiezzi, Daniel G.
Herpel, Esther
Taran, Florin Andrei
Modugno, Francesmary
Keeney, Gary
Nelson, Gregg
Steed, Helen
Song, Honglin
Luk, Hugh
Benitez, Javier
Alsop, Jennifer
Koziak, Jennifer M.
Lester, Jenny
Rothstein, Joseph H.
de Andrade, Jurandyr M.
Lundvall, Lene
Paz-Ares, Luis
Robles-Díaz, Luis
Wilkens, Lynne R.
Garcia, Maria J.
Intermaggio, Maria P.
Alcaraz, Marie-Lyne
Brett, Mary A.
Beckmann, Matthias W.
Jimenez-Linan, Mercedes
Anglesio, Michael
Carney, Michael E.
Schneider, Michael
Traficante, Nadia
Pejovic, Nadja
Singh, Naveena
Le, Nhu
Sinn, Peter
Ghatage, Prafull
Erber, Ramona
Edwards, Robert
Vierkant, Robert
Ness, Roberta B.
Leung, Samuel
Orsulic, Sandra
Brucker, Sara Y.
Kaufmann, Scott H.
Fereday, Sian
Gayther, Simon
Winham, Stacey J.
Kommoss, Stefan
Pejovic, Tanja
Longacre, Teri A.
McGuire, Valerie
Rhenius, Valerie
Sieh, Weiva
Shvetsov, Yurii B.
Whittemore, Alice S.
Staebler, Annette
Karlan, Beth Y.
Rodriguez-Antona, Cristina
Bowtell, David D.
Goode, Ellen L.
Høgdall, Estrid
Candido dos Reis, Francisco J. http://orcid.org/0000-0001-5758-5917
Gronwald, Jacek
Chang-Claude, Jenny
Moysich, Kirsten B.
Kelemen, Linda E.
Cook, Linda S.
Goodman, Marc T.
Fasching, Peter A.
Crawford, Robin
Deen, Suha
Menon, Usha
Huntsman, David G.
Köbel, Martin
Ramus, Susan J.
Pharoah, Paul D. P.
Brenton, James D. http://orcid.org/0000-0002-5738-6683
Article History
Received: 1 January 2020
Revised: 14 March 2020
Accepted: 29 April 2020
First Online: 18 June 2020
Ethics approval and consent to participate
: The study was performed in accordance with the Declaration of Helsinki. All institutions participating in the Ovarian Tumour Tissue Analysis Consortium got institutional review board/ethics board approval. In most studies, patients consented to participate. In five studies, the need for informed consent was waived by the ethics board (InternalRef removed).
: The R markdown document containing the entire data set and allowing for reproducing all analyses performed in this manuscript is available as supplementary files.
: F.C.M. is a Clinical Lecturer for the Experimental Medicine Initiative from the University of Cambridge that is partly funded by AstraZeneca. A.P. was funded by NIHR (Academic Clinical Fellowship). A.D.F. has received a research grant from AstraZeneca, not directly to this work. D.D.B. receives funding from Astra Zeneca and Genentech Roche for the conduct of research studies and clinical trials unrelated to the work described in this article. D.G.H. is a founder and Chief Medical Officer of Contextual Genomics, a somatic mutation testing laboratory; the company’s work and interests do not overlap with the subject of and methodologies used in this article. U.M. has stock ownership and has received research funding from Abcodia. No other disclosures are reported. P.D.P.P. is a member of the <i>British Journal Cancer</i> Editorial Board. All other authors declare no competing interests.
: F.C.M. is funded by the Experimental Medicine Initiative from the University of Cambridge, by the Academy of Medical Sciences (SGL016_1084), Cancer Research UK (C53876/A24267) and by the Addenbrooke’s Charitable Trust (REF 13/17). Funding was provided by Canadian Institutes for Health Research (MOP-86727); Brazilian National Council for Scientific and Technological Development, grant No. 478416/2009-1; Calgary Laboratory Services Internal Research Competition RS10-533; German Federal Ministry of Education and Research of Germany (01 GB 9401); German Cancer Research Center (DKFZ); US National Cancer Institute K07-CA80668, P50-CA159981, R01CA095023; National Institutes of Health/National Center for Research Resources/General Clinical Research Center grant MO1-RR000056; US Army Medical Research and Materiel Command DAMD17-02-1-0669; NIH (R01-CA122443, P50-CA136393, P30-CA15083, U01-CA71966, U01-CA69417, R01-CA16056, K07-CA143047); Cancer Research UK (C490/A10119, C490/A10123, C490/A16561); UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge and at University College Hospital, ‘Women’s Health Theme’; NIH SFB 685; the Eve Appeal; the Oak Foundation and Deutsche Forschungsgemein-schaft. The Australian Ovarian Cancer Study Group was supported by the US Army Medical Research and Materiel Command under DAMD17-01-1-0729; The Cancer Council Victoria; Queensland Cancer Fund; The Cancer Council, New South Wales; the Tom Baker Cancer Centre Translational Laboratories; The Cancer Council, South Australia; The Cancer Foundation of Western Australia; The Cancer Council Tasmania and the National Health and Medical Research Council of Australia (NHMRC; ID400413, ID400281). The AOCS gratefully acknowledges additional support from the Peter MacCallum Cancer Foundation and Ovarian Cancer Australia (OCA). The Gynaecological Oncology Biobank at Westmead, a member of the Australasian Biospecimen Network-Oncology group, was funded by the National Health and Medical Research Council Enabling grants ID 310670 and ID 628903 and the Cancer Institute NSW grants 12/RIG/1-17 and 15/RIG/1-16. Funding for MALOVA was provided by research grant R01-CA61107 from the National Cancer Institute, Bethesda, Maryland; research grant 94 222 52 from the Danish Cancer Society, Copenhagen, Denmark and the Mermaid I project. A.D.F. is funded by Cancer Institute NSW grant 15/TRC/1-01. B.Y.K. is funded by the American Cancer Society Early Detection Professorship (SIOP-06-258-01-COUN) and the National Center for Advancing Translational Sciences (NCATS), grant UL1TR000124. The samples from the German Ovarian Cancer Study were provided by the tissue bank of the National Center for Tumor Diseases (NCT, Heidelberg, Germany) in accordance with the regulations of the tissue bank and the approval of the ethics committee of Heidelberg University. F.J.C.d.R. is funded by the Brazilian National Council for Scientific and Technological Development – CNPq (427983/2016-9, 303210/2018-4). The UKOPS study was funded by The Eve Appeal (The Oak Foundation) with investigators supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. A.T. is funded through a Michael Smith Foundation for Health Research Scholar Award. M.A. is funded through a Michael Smith Foundation for Health Research Scholar Award and the Janet D. Cottrelle Foundation Scholars programme managed by the BC Cancer Foundation. D.G.H. receives support from the Dr. Chew Wei Memorial Professorship in Gynecologic Oncology and the Canada Research Chairs programme (Research Chair in Molecular and Genomic Pathology). OVCARE (including the VAN study) receives support through the BC Cancer Foundation and The VGH + UBC Hospital Foundation (relevant for authors A.T., D.G.H, S.L., C.C., A.N.K., and M.A.). J.D.B. acknowledges funding and support from Cancer Research UK (grant numbers A22905, A15601 and A17197). The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript and decision to submit the manuscript for publication.