Funding for this research was provided by:
National Science Foundation (1734853, 1636840, 1416953, 0716055 and 1023115)
Received: 2 December 2019
Revised: 13 May 2020
Accepted: 29 May 2020
First Online: 22 June 2020
Ethics approval and consent to participate
: The study was carried out in accordance with the Declaration of Helsinki. Data used in this study were collected as part of routine medical records. The Regional Research Ethics Committee at the University Hospitals of Geneva has approved the data collection and management processes. Informed consent was obtained from all participants included in the study before genetic testing.
: Not applicable.
: The datasets used and analysed during the current study are available from the corresponding author upon reasonable request and gaining signed clinical data transfer agreement from Geneva University Hospital. We also shared the computational protocol via GitHub (ExternalRef removed).
: The authors declare no competing interests.
: This work was supported by the University of Basel and the Freiwillige Akademische Gesellschaft (FAG) to Chang Ming. Research related to ML algorithms was supported in part by the U.S. National Science Foundation (Grant Numbers 1916425, 1734853, 1636840 and 1416953) and the National Institutes of Health (Grants P20 NR015331, P30 DK089503, UL1TR002240, R01CA233487 and R01MH12107) to Ivo D. Dinov, PhD. The funders had no role in study design, data collection and analyses, decision to publish or preparation of this paper.