Funding for this research was provided by:
Prostate Cancer UK (RIA-030-15, RIA-030-15)
Received: 2 August 2019
Revised: 11 May 2020
Accepted: 4 June 2020
First Online: 25 June 2020
Ethics approval and consent to participate
: All animal operations were approved by the Animal Ethics Committee, University of Exeter, U.K. Patients were recruited and consented under Genomics England’s 100,000 Genome Project ethics at University College Hospital, with a subset of patients also consented under UCL/UCLH Biobank ethics (REC 15/YH/0311). The study was performed in accordance with the declaration of Helsinki.
: All subjects gave written consent for publication.
: Materials, data and associated protocols are available upon request. Supplementary information is available for this paper online.
: The authors declare no competing interests.
: S.P. was supported by a Research Innovation Award from Prostate Cancer UK (RIA-030-15). We are very grateful to GeneTools LLC, Alexandra Vincent and Jim Summerton for technical advice and for the provision of reagents.