Grimes, David Robert http://orcid.org/0000-0003-3140-3278
Jansen, Marnix
Macauley, Robert J.
Scott, Jacob G.
Basanta, David
Funding for this research was provided by:
Cancer Research UK (A19834)
Wellcome Trust (214461/Z/18/Z)
U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (K12CA076917, U01CA202958-01)
U.S. Department of Health & Human Services | NIH | Division of Loan Repayment (P30CA043703)
U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute
Article History
Received: 16 April 2020
Revised: 24 June 2020
Accepted: 23 July 2020
First Online: 27 August 2020
Ethics approval and consent to participate
: Ethics approval for the gathering of the data used in this study was granted by an Advarra Institutional review board at the Moffitt Cancer Center, designation MCC18506, with informed patient consent for all samples analysed. All human data were anonymised, and obtained in accordance with the code of conduct of research of the MCC and the IRB under national and international standards.
: Not applicable.
: Simulation parameters and details available in the manuscript and Supplementary Material. Further details of the data analysed in this work are available from the corresponding author on request.
: The authors declare no competing interests.
: D.R.G. thanks Cancer Research UK for the travel grant that made this work possible, and the Wellcome trust for their support. We thank the Integrated Mathematical Oncology department at the H. Lee Moffitt Cancer Center and Research Institute. D.R.G. also acknowledges the contributions of NVIDIA research for their generous hardware donations, while D.B. acknowledges the National Institute of Cancer (NCI) for Grant U01CA202958-01 and Florida Health’s Bankhead Coley for 20B06. J.G.S. is grateful to the NIH Loan Repayment programme, the NIH Case Comprehensive Cancer Center (support grant P30CA043703) and the Calabresi Clinical Oncology Research Programme, National Cancer Institute (award number K12CA076917). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.