Maiques, Oscar
Fanshawe, Bruce
Crosas-Molist, Eva
Rodriguez-Hernandez, Irene http://orcid.org/0000-0002-6487-452X
Volpe, Alessia
Cantelli, Gaia
Boehme, Lena http://orcid.org/0000-0001-7593-7533
Orgaz, Jose L.
Mardakheh, Faraz K.
Sanz-Moreno, Victoria http://orcid.org/0000-0002-5096-9456
Fruhwirth, Gilbert O. http://orcid.org/0000-0002-1438-2674
Funding for this research was provided by:
Barts Charity
King’s Health Partners (PhD studentship from the King’s Bioscience Institute, PhD studentship by the King’s Medical Research Trust Joint Research Committee)
Cancer Research UK ([C33043/A12065] and [C33043/A24478], [C33043/A12065] and [C33043/A24478], [C33043/A12065] and [C33043/A24478], [C33043/A12065] and [C33043/A24478])
Fundacion Ramon Areces Barts Charity
EC | Horizon 2020 Framework Programme (Marie Sklodowska-Curie Action [H2020-MSCA-IF-2014-EF-ST])
Barts Charity Fundacion Alfonso Martin Escudero
Royal Society ([RG110591])
Harry J. Lloyd Charitable Trust
Article History
Received: 24 March 2020
Revised: 23 March 2021
Accepted: 13 May 2021
First Online: 25 June 2021
Ethics approval and consent to participate
: Humans: no new patient data were collected in this study. All patient data were already publicly available in the National Cancer Institute’s TCGA and NCBI’s GEO databases. TCGA Ethics & Policies was originally published by the National Cancer Institute. Individual ethics approval and consent information of GEO datasets can be found in the respective datasets using the GEO Accession Viewer. Animals: All experimental protocols were monitored and approved by the King’s College London Animal Welfare and Ethical Review Body Animal Welfare and Ethical Review Panel, in accordance with UK Home Office regulations (Project License 70/8879) under the Animals (Scientific Procedures) Act 1986 and UK National Cancer Research Institute (NCRI) Guidelines for the Welfare and Use of Animals in Cancer Research.
: Patient data were from publicly available databases; please see there for details regarding consent.
: Gene expression datasets re-analysed in this study are available from TCGA and NCBI GEO under accession numbers: GSE4570, GSE4840, GSE4843, GSE4841, GSE23764, GSE8401, GSE7553 and GSE46517.
: The authors declare no competing interests.
: GOF’s lab was supported by Cancer Research UK [C48390/A21153], Worldwide Cancer Research [16-1153], and King’s Health Partners [King’s Medical Research Trust Joint Research Committee studentship to A.V.]. B.F. was supported by a King’s Health Partners studentship to V.S.M. and G.O.F. V.S.M.’s lab was supported by Cancer Research UK [C33043/A12065] and [C33043/A24478] (V.S.M., E.C.M., J.L.O., L.B. and GC), the Royal Society [RG110591] (V.S.M.), The Harry J. Lloyd Charitable Trust (J.L.O. and V.S.M.), the Barts Charity (V.S.M., J.L.O., O.M., I.R.H. and E.C.M.), the Fundacion Alfonso Martin Escudero and Marie Sklodowska-Curie Action [H2020-MSCA-IF-2014-EF-ST] (I.R.H.), and Fundacion Ramon Areces (E.C.M.). F.M. was supported by an MRC Career Development Award (MR/P009417/1). This work was further supported by the Department of Health (DoH) via the National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre award to King’s Health Partners, and the Wellcome/EPSRC Centre for Medical Engineering [WT203148/Z/16/Z]. Views expressed are those of the authors and not necessarily those of the NHS, NIHR or DoH.