Aliagas, Elisabet
Alay, Ania
Martínez-Iniesta, Maria
Hernández-Madrigal, Miguel
Cordero, David
Gausachs, Mireia
Pros, Eva
Saigí, Maria http://orcid.org/0000-0001-5815-5388
Busacca, Sara
Sharkley, Annabel J.
Dawson, Alan
Palmero, Ramón
Ruffinelli, José C.
Padrones, Susana
Aso, Samantha
Escobar, Ignacio
Ramos, Ricard
Llatjós, Roger
Vidal, August http://orcid.org/0000-0001-5727-2099
Dorca, Eduard
Varela, Mar
Sánchez-Céspedes, Montse
Fennell, Dean
Muñoz-Pinedo, Cristina
Villanueva, Alberto
Solé, Xavi http://orcid.org/0000-0002-2197-3325
Nadal, Ernest http://orcid.org/0000-0002-9674-5554
Article History
Received: 18 April 2021
Revised: 6 August 2021
Accepted: 3 September 2021
First Online: 29 September 2021
Competing interests
: EN received research support from Roche, Pfizer, Bristol Myers Squibb and Merck Serono and participated in advisory boards from Bristol Myers Squibb, Merck Serono, Merck Sharpe & Dohme, Lilly, Roche, Pfizer, Takeda, Boehringer Ingelheim, Bayer, Amgen and Astra Zeneca. RP has participated in advisory boards from Bristol Myers Squibb, Merck Sharpe & Dohme, Roche, Pfizer, Lilly, Boehringer Ingelheim and Astra Zeneca. DF has received research support from Astex Therapeutics, Astra Zeneca, Bayer, Boehringer Ingelheim, Bristol Myers Squibb, Clovis Oncology, Merck Sharpe & Dohme, Lilly Oncology, Roche and participated in advisory boards from Atara Therapeutics, Bayer, Boehringer Ingelheim and Inventiva. The other authors declare no competing interests.
: The retrospective cohort was approved by a National Ethical Committee, under the references 4/LO/1527 (a translational research platform entitled <i>Predicting Drug and Radiation Sensitivity in Thoracic Cancers—also approved by University Hospitals of Leicester NHS Trust under the reference IRAS131283</i>) and 14/EM/1159 (retrospective cohort). Pleural effusions samples were obtained after patients signed the informed consent approved by the Hospital de Bellvitge Ethical Committee (PR152/14). All the animal experiments were performed in accordance with protocols approved by Animal Research Ethics Committee at IDIBELL. This study was performed in accordance with the principles outlined in the Declaration of Helsinki.