de Boo, Leonora W. http://orcid.org/0000-0003-3367-1022
Jóźwiak, Katarzyna
Joensuu, Heikki http://orcid.org/0000-0003-0281-2507
Lindman, Henrik
Lauttia, Susanna http://orcid.org/0000-0001-7699-8581
Opdam, Mark http://orcid.org/0000-0001-5832-6386
van Steenis, Charlaine
Brugman, Wim
Kluin, Roelof J. C.
Schouten, Philip C. http://orcid.org/0000-0002-0822-7133
Kok, Marleen
Nederlof, Petra M. http://orcid.org/0000-0002-2358-9765
Hauptmann, Michael http://orcid.org/0000-0001-8539-0148
Linn, Sabine C. http://orcid.org/0000-0001-5541-0347
Funding for this research was provided by:
KWF Kankerbestrijding (10603)
Article History
Received: 14 July 2021
Revised: 16 December 2021
Accepted: 17 January 2022
First Online: 5 February 2022
Competing interests
: HJ has ownership interest (including patents) at Sartar Therapeutics and is a board member, has a co-appointment at Orion Pharma and is employed by Orion Pharma and has received fees from Neutron Therapeutics. SCL reports grants from ZonMw and A Sister’s Hope during the conduct of the study. SCL is an advisory board member for AstraZeneca, Cergentis, IBM, Pfizer and Roche and received institutional research grants from Agendia, AstraZeneca, Eurocept-pharmaceuticals and Pfizer. In addition, SCL received institutional research grants and institutional non-financial support from Agendia, Genentech, Novartis, Roche, Tesaro and Immunomedics and other institutional support from AstraZeneca, Pfizer, Cergentis, Daiichi Sankyo, IBM and Bayer outside the submitted work. MK is an advisory board member for BMS, Roche, MSD and Daiichi and received institutional research support from AstraZeneca, BMS and Roche outside the submitted work. The remaining authors declare no competing interests.
: The study was approved by the Ethics Committee of the participating medical institutions and the National Agency for Medicines, Finland. Patients provided written informed consent to allow the use of their tumour tissue for clinical study-related research purposes. The Institutional Review Boards at Helsinki University, Finland, approved the use of archival tissue for the current translational study. The study was performed in accordance with the Declaration of Helsinki.
: Not applicable.