Article History
Received: 23 August 2022
Revised: 11 January 2023
Accepted: 9 March 2023
First Online: 27 March 2023
Competing interests
: The authors declare no competing interests.
: Informed consent was obtained from study participants.
: The informed consent was obtained from study participants. Tumor tissues and adjacent non-tumor tissues of 48 paired HCC cases were obtained from Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University. All procedures were approved by the Ethics Committee of Hunan Cancer Hospital. Signed informed consent was obtained from each patient. All animal experiment protocols were permitted by the Animal Ethics Committee of Hunan Cancer Hospital.