Funding for this research was provided by:
Ministry of Science, ICT and Future Planning (2017M3C7A1043842, 2016M3C7A1904148)
Received: 15 July 2020
Revised: 2 March 2021
Accepted: 4 March 2021
First Online: 22 March 2021
Compliance with ethical standards
: The authors declare no competing interests.
: The current study was approved by the appropriate local ethics committee. Neuropathological processing of control and CTE human brain samples was performed according to the procedures previously established by the BUADC and CTE Center. Institutional review board approval for ethical permission was obtained through the BUADC and CTE Center [CitationRef removed, CitationRef removed]. This study was reviewed by the Boston University School of Medicine Institutional Review Board (Protocol H-28974) and was approved as exempt because the study involved only tissue collected from post-mortem individuals that are not classified as human subjects. Nevertheless, next of kin provided informed consent for participation and brain donation. The study was performed in accordance with the institutional regulatory guidelines and principles of human subject protection in the Declaration of Helsinki. All animal care and handling were approved by the institutional guidelines of Institutional Animal Care and Use Committee at the Korea Institute of Science and Technology (IACUC-2017-056) and Kyungpook National University Animal Care Committee (KNU 2019-90).