Musiu, Chiara http://orcid.org/0000-0003-1647-5708
Caligola, Simone http://orcid.org/0000-0002-9829-9527
Fiore, Alessandra
Lamolinara, Alessia
Frusteri, Cristina
Del Pizzo, Francesco Domenico
De Sanctis, Francesco
Canè, Stefania
Adamo, Annalisa
Hofer, Francesca
Barouni, Roza Maria
Grilli, Andrea
Zilio, Serena
Serafini, Paolo
Tacconelli, Evelina
Donadello, Katia
Gottin, Leonardo
Polati, Enrico
Girelli, Domenico
Polidoro, Ildo
Iezzi, Piera Amelia
Angelucci, Domenico
Capece, Andrea
Chen, Ying
Shi, Zheng-Li http://orcid.org/0000-0001-8089-163X
Murray, Peter J.
Chilosi, Marco
Amit, Ido
Bicciato, Silvio http://orcid.org/0000-0002-1944-7078
Iezzi, Manuela http://orcid.org/0000-0002-6296-6498
Bronte, Vincenzo http://orcid.org/0000-0002-3741-5141
Ugel, Stefano http://orcid.org/0000-0002-6639-7608
Funding for this research was provided by:
Cancer Research Institute (CLIP 2020)
Ministero dell'Istruzione, dell'Università e della Ricerca (B38D19000260006, B38D19000140006)
Associazione Italiana per la Ricerca sul Cancro (23788, 21509)
Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona (Enact)
Fondazione TIM (Project: Immunovid) European Research Commission
Ministero dell'Istruzione, dell'Università e della Ricerca
Article History
Received: 6 May 2021
Revised: 30 August 2021
Accepted: 31 August 2021
First Online: 13 September 2021
Competing interests
: A.F., S.U., and V.B. hold proprietary rights on the patent applications about engineered cells for inducing tolerance by BioNTech (Mainz, Germany). S.Z., V.B., and P.S. hold proprietary rights on the patent applications about 4PD technology by the University of Miami (Miami, USA). No potential conflicts of interest were disclosed by the other authors.
: Our studies include human participants, human data, or human tissues. All the patients (and/or initially their families) provided written informed consent before sampling and for the use of their clinical and biological data. This study was approved by the local ethical committee (protocol 17963; PI: Vincenzo Bronte; ClinicalTrials.gov identifier NCT04438629). All clinical investigations were conducted according to the Declaration of Helsinki principles, and informed consent was obtained from all study participants. Animal experiments were performed according to national (protocol number C46F4.26 approved by the Ministerial Decree Number 993/2020-PR of July 24, 2020 [PI: Stefano Ugel] and protocol number C46F4.8 approved by the Ministerial Decree Number 207/2018-PR of February 21, 2018 [PI: Vincenzo Bronte]) and European laws and regulations. All animal experiments were approved by Verona University Ethical Committee and conducted according to the guidelines of Federation of European Laboratory Animal Science Association (FELASA).