Novak, Rostislav http://orcid.org/0000-0002-9044-8524
Ahmad, Yamen Abu
Timaner, Michael
Bitman-Lotan, Eliya
Oknin-Vaisman, Avital
Horwitz, Roi
Hartmann, Oliver
Reissland, Michaela http://orcid.org/0000-0002-4704-9392
Buck, Viktoria
Rosenfeldt, Mathias http://orcid.org/0000-0001-7650-8458
Nikomarov, David
Diefenbacher, Markus Elmar http://orcid.org/0000-0002-7402-7949
Shaked, Yuval
Orian, Amir http://orcid.org/0000-0002-8521-1661
Funding for this research was provided by:
Deutsche Krebshilfe (DKH 70114554, DKH 70114554)
German-Israeli Foundation for Scientific Research and Development (1431, 1431)
Deutsche Forschungsgemeinschaft (GRK2243)
Israel Cancer Research Fund (AO-1017)
Article History
Received: 4 August 2022
Revised: 8 September 2022
Accepted: 12 September 2022
First Online: 24 September 2022
Competing interests
: The authors declare no competing interests
: All authors consented to publication of this paper.
: Mesenchymal-derived cells: Human MSCs, irrespective of sex, were obtained from patient’s bone marrow during trauma operations for accidental injury that were otherwise healthy individuals in the Orthopedic Department at Rambam Health Campus Center (Israel). Cells were collected from a total of 23 patients (20 males and three females) aged 20–60 years. Informed consent was obtained from all patients. Experiments were according to the Helsinki Declaration and ICH-GCP Guidelines, Ethics Approval 0180-14 – Helsinki Committee, Rambam Health Care Campus, Israel”.Human sarcoma samples: Human samples, irrespective of sex, were obtained from the Pathology Department at the University Hospital Würzburg (Germany). Informed consent was obtained from all patients. Experiments were in agreement with the principles set out in the WMA Declaration of Helsinki and the Department of Health and Human Services Belmont Report. Samples were approved under Ethics Approval 17/01/2006 (University Hospital Würzburg).