Anagnostopoulos, Gerasimos http://orcid.org/0000-0002-2042-8675
Saavedra, Ester
Lambertucci, Flavia
Motiño, Omar http://orcid.org/0000-0002-3858-0966
Dimitrov, Jordan http://orcid.org/0000-0001-8536-8995
Roiz-Valle, David
Quesada, Victor
Alvarez-Valadez, Karla
Chen, Hui
Sauvat, Allan http://orcid.org/0000-0001-7076-8638
Rong, Yan
Nogueira-Recalde, Uxía
Li, Sijing
Montégut, Léa
Djavaheri-Mergny, Mojgan
Castedo, Maria
Lopez-Otin, Carlos
Maiuri, Maria Chiara http://orcid.org/0000-0001-9760-7674
Martins, Isabelle http://orcid.org/0000-0003-0885-613X
Kroemer, Guido http://orcid.org/0000-0002-9334-4405
Article History
Received: 10 December 2023
Revised: 15 March 2024
Accepted: 25 March 2024
First Online: 6 April 2024
Competing interests
: GK has been holding research contracts with Daiichi Sankyo, Eleor, Kaleido, Lytix Pharma, PharmaMar, Osasuna Therapeutics, Samsara Therapeutics, Sanofi, Tollys, and Vascage. GK has been consulting for Reithera. GK is on the Board of Directors of the Bristol Myers Squibb Foundation France. GK is a scientific co-founder of everImmune, Osasuna Therapeutics, Samsara Therapeutics and Therafast Bio. GK is in the scientific advisory boards of Hevolution, Institut Servier and Longevity Vision Funds. GK is the inventor of patents covering therapeutic targeting of aging, cancer, cystic fibrosis and metabolic disorders. GK, IM and OM are inventors of patent covering the therapeutic use of anti-ACBP/DBI antibodies. GK’s wife, Laurence Zitvogel, has held research contracts with Glaxo Smyth Kline, Incyte, Lytix, Kaleido, Innovate Pharma, Daiichi Sankyo, Pilege, Merus, Transgene, 9 m, Tusk and Roche, was on the Board of Directors of Transgene, is a cofounder of everImmune, and holds patents covering the treatment of cancer and the therapeutic manipulation of the microbiota. GK’s brother, Romano Kroemer, was an employee of Sanofi and now consults for Boehringer-Ingelheim. The others co-authors declare no conflict of interest.
: All animal experiments were conducted in accordance with the local Animal Experimental Ethics Committee (protocols ##25355-2020050715057113 v4, ##31411-2021050411267667 v3, #31018-2021041210419925 v4 and #25000-2020040718432518 v4).