Received: 30 September 2020
Accepted: 26 February 2021
First Online: 13 April 2021
Ethics approval and consent to participate
: Informed consent was obtained from all enrolled patients from the First Affiliated Hospital of Guangzhou Medical University, the Fifth Affiliated Hospital of Sun Yat-Sen University, Yangjiang People’s Hospital and Qingyuan People’s Hospital. The overall study was reviewed and approved by the ethics committees of all the four hospitals. The institutional review board of BGI-Shenzhen approved the sequencing and downstream analyses of samples collected by the aforementioned hospitals under the ethical clearance no. BGI-IRB 20008.
: The authors declare no competing interests.