Kerr, Shona M. http://orcid.org/0000-0002-4137-1495
Cowan, Emma http://orcid.org/0000-0003-1367-930X
Klaric, Lucija http://orcid.org/0000-0003-3105-8929
Bell, Christine
O’Sullivan, Dawn
Buchanan, David
Grzymski, Joseph J. http://orcid.org/0000-0003-2646-8958
van Hout, Cristopher V. http://orcid.org/0000-0001-9689-5344
Tzoneva, Gannie
Shuldiner, Alan R.
Wilson, James F. http://orcid.org/0000-0001-5751-9178
Miedzybrodzka, Zosia http://orcid.org/0000-0003-2890-8136
Funding for this research was provided by:
RCUK | Medical Research Council (MC_UU_00007/10, MC_UU_00007/10, MC_UU_00007/10)
Research Councils UK (MR/R026408/1, MR/R026408/1, MR/R026408/1)
Chief Scientist Office (CZB/4/276, CZB/4/710, CZB/4/276, CZB/4/710)
Article History
Received: 2 August 2022
Revised: 20 December 2022
Accepted: 18 January 2023
First Online: 16 March 2023
Competing interests
: AS, CVVH and GT are former employees and/or stockholders of Regeneron Genetics Center or Regeneron Pharmaceuticals.
: It is clear that information robustly linking genetic variants (e.g. <i>BRCA1</i> V1736A) with specific conditions (e.g. breast and ovarian cancer) is fundamental biological knowledge, not personal information, and therefore should not require specific consent for clinicians to share [CitationRef removed]. In contrast, neither identifiable medical details about the patients, nor their personal identifiers, were shared by the clinical team with the research team. Eligible participants were recruited to ORCADES, Research Ethics Committee references 26-11-2003 and 12/SS/0151. Research participants gave written informed consent for research procedures including electronic health record linkage. The data linkage and access to NHS Scotland-originated data for the ORCADES cohort was approved by the Public Benefit and Privacy Panel for Health and Social Care (Ref 1718-0380). This research has also been conducted using data from UK Biobank, as part of project ID number 19655. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.