McRonald, Fiona E. http://orcid.org/0000-0001-7226-9461
Pethick, Joanna
Santaniello, Francesco http://orcid.org/0000-0002-8500-1656
Shand, Brian
Tyson, Adele http://orcid.org/0000-0003-0135-7397
Tulloch, Oliver
Goel, Shilpi
Lüchtenborg, Margreet
Borthwick, Gillian M.
Turnbull, Clare
Shaw, Adam C.
Monahan, Kevin J.
Frayling, Ian M. http://orcid.org/0000-0002-3420-0794
Hardy, Steven
Burn, John http://orcid.org/0000-0002-9823-2322
Article History
Received: 8 August 2023
Revised: 8 January 2024
Accepted: 23 January 2024
First Online: 15 February 2024
Competing interests
: JB was awarded funding from Bowel Cancer UK (grant 18PG0019), which provided primary funding for the bioinformatics aspects of this work. CT is Chief Investigator for the CRUK Programme CanGene-CanVar (grant C61296/A27223), which provided additional funding for the bioinformatics aspects of this work. ACS is partly funded by the NHS South East Genomic Medicine Service as Co-Chair of the National Lynch syndrome diagnosis transformation project. IMF has received travel support from St Vincent’s University Hospital, Dublin. He is an Assessor for the UK National External Quality Assessment Service for immunocytochemistry and in situ hybridisation (UK NEQAS ICC&ISH), receiving honoraria and travel expenses. He also undertakes unpaid roles as Honorary Treasurer & Trustee, International Society for Gastrointestinal Hereditary Tumours (InSiGHT); President & Trustee, Association of Clinical Pathologists, UK; and Member of Council, UK Cancer Genetics Group. KJM has previously received funding from 40tude cancer charity, and sits on the Medical Advisory Board for Bowel Cancer UK and Lynch Syndrome UK. All other authors have declared no competing interests.
: Data used in this study were routinely collected by NDRS as part of NHS patient care and support. No human or animal subjects were used. Further ethical approval for this study was not required per the definition of research according to the UK Policy Framework for Health and Social Care Research.