Kim, Tae Hyun http://orcid.org/0000-0003-3856-5325
Wang, Yang
Oliver, C. Ryan
Thamm, Douglas H.
Cooling, Laura
Paoletti, Costanza
Smith, Kaylee J.
Nagrath, Sunitha http://orcid.org/0000-0002-1497-7977
Hayes, Daniel F. http://orcid.org/0000-0003-3620-7575
Article History
Received: 31 May 2018
Accepted: 11 March 2019
First Online: 1 April 2019
Competing interests
: D.F.H. is the named inventor on a patent granted to the University of Michigan regarding novel capture and characterizations of circulating tumor cells, which is licensed to Menarini SiliconBiosystems, LLC, manufacturer of the CellSearch® system. This patent is not directly related to this manuscript or the work described, but ultimately characterization of CTC for clinical purposes could be affected. He has no other conflicts related to this work. He reports serving as an external advisor to the following companies; Cepheid, Freenome, Cellworks, Agendia, and CVS Caremark. He has received research funding from Merrimak Pharmaceuticals, Eli LIlly Company, Menarini Silicon Biosystems, Puma Biotechnology, Pfizer, and Astra Zeneca. He has stock options with Oncimmune LLC and InBiomotion. Patent Application: The Regents of the University of Michigan. Inventor: Daniel F.Hayes. Patent No.: US 9,568,476 B2. Status; Filed: June 13, 2014; Approved: Feb 14, 2017. Specific aspect of manuscript covered in patent application: none directly at present. However, the patent covers phenotyping of captured CTCs for directing care of patients with metastatic breast cancer. With successful application of the indwelling CTC system described, this patent will cover doing so. C.P. has received research funding from AstraZeneca and Pfizer. The remaining authors declare no competing interests.