Funding for this research was provided by:
National Natural Science Foundation of China (61721003)
Received: 21 February 2018
Accepted: 31 July 2019
First Online: 22 October 2019
: The authors declare competing interests as following: Z.X., H.H. W.L. and Y.L. are shareholders of Syngentech Inc; Z.X., H.H., Y.L. and W.L. have filed a patent application (PCT/CN2017/096043) to State Intellectual Property Office of China based on the findings in this work. Tsinghua University and Syngentech Inc. are the patent applicants. Z.X., H.H., Y.L. and W.L. are the co-inventors. The patent describes the application of mutual inhibition gene circuit in oncolytic adenovirus in the manuscript.