Received: 22 April 2020
Accepted: 21 August 2020
First Online: 30 September 2020
Change Date: 24 November 2020
Change Type: Correction
Change Details: A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20117-z
: P.K.J., L.T.N., and B.M.S. are listed as inventors on the following patent applications related to the content of this work: (1) Highly sensitive nucleic acid detection using modified CRISPR/Cas. Applicant: University of Florida. Inventors: P.K.J. and L.T.N. Status: Patent pending. US Patent App. 62/932,823; US Patent App. 62/988,679, and US Patent App. 63/001,056. Increasing Cas-mediated trans-cleavage activity and enhancing the detection of nucleic acid targets by extending crRNAs. (2) Engineered CRISPR/Cas systems for detecting DNA/RNA heteroduplexes and methylated DNA. Applicant: University of Florida. Inventors: P.K.J., L.T.N., and B.M.S. Status: Patent pending. US Patent App. 62/ 952,762. Application of extended crRNAs (CRISPR-ENHANCE) for detecting an RNA via DNA/RNA heteroduplex and methylated DNA. (3) Trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detection. Applicant: University of Florida. Inventors: P.K.J. and L.T.N. Status: Patent pending. US Patent App. 63/010,382. Enhancement of trans-cleavage activity by nucleic acid extensions on the crRNA. Application of CRISPR-ENHANCE for detecting SARS-CoV-2 genetic material.