de Nonneville, Alexandre http://orcid.org/0000-0001-6710-8284
Reddel, Roger R. http://orcid.org/0000-0002-6302-6107
Article History
Received: 2 May 2020
Accepted: 2 February 2021
First Online: 10 March 2021
Competing interests
: R.R.R. is listed as a joint inventor on a patent regarding the C-circle assay: European Patent 10818148.8, US Patent US 08999643, Chinese Patent 201080048175.X: “Methods and assays for the detection of Alternative Lengthening of Telomeres (ALT) activity in cells”; Children’s Medical Research Institute, Inventors: Jeremy D. Henson and Roger R. Reddel.
: This Matters Arising comment is a non-interventional, retrospective analysis and commentary on published data, publicly available within the Nature Communications paper “Sieverling, L. et al. Genomic footprints of activated telomere maintenance mechanisms in cancer. <i>Nat. Commun</i>. <b>11</b>, 1–13 (2020).” and its supplementary information files. Therefore, no ethics board/committee’s approval or formal patient consent was required. As described in Sieverling et al., the Ethics oversight for the PCAWG protocol was undertaken by the TCGA Program Office and the Ethics and Governance Committee of the ICGC; each individual ICGC and TCGA project that contributed data to PCAWG had its own local arrangements for ethics oversight and regulatory alignment.