Koehler Leman, Julia http://orcid.org/0000-0002-5693-3593
Lyskov, Sergey http://orcid.org/0000-0001-6380-6712
Lewis, Steven M.
Adolf-Bryfogle, Jared http://orcid.org/0000-0001-8586-1907
Alford, Rebecca F.
Barlow, Kyle http://orcid.org/0000-0002-9787-0066
Ben-Aharon, Ziv http://orcid.org/0000-0002-9623-6071
Farrell, Daniel http://orcid.org/0000-0001-7024-7998
Fell, Jason http://orcid.org/0000-0001-6680-2936
Hansen, William A.
Harmalkar, Ameya http://orcid.org/0000-0001-6863-9634
Jeliazkov, Jeliazko http://orcid.org/0000-0003-4249-1955
Kuenze, Georg
Krys, Justyna D. http://orcid.org/0000-0002-5318-8831
Ljubetič, Ajasja http://orcid.org/0000-0002-2171-1579
Loshbaugh, Amanda L.
Maguire, Jack
Moretti, Rocco
Mulligan, Vikram Khipple
Nance, Morgan L. http://orcid.org/0000-0003-0997-9393
Nguyen, Phuong T.
Ó Conchúir, Shane
Roy Burman, Shourya S. http://orcid.org/0000-0001-9274-9104
Samanta, Rituparna
Smith, Shannon T. http://orcid.org/0000-0002-1225-8928
Teets, Frank
Tiemann, Johanna K. S. http://orcid.org/0000-0001-7551-6245
Watkins, Andrew
Woods, Hope http://orcid.org/0000-0001-6615-545X
Yachnin, Brahm J. http://orcid.org/0000-0001-6812-6329
Bahl, Christopher D.
Bailey-Kellogg, Chris
Baker, David http://orcid.org/0000-0001-7896-6217
Das, Rhiju http://orcid.org/0000-0001-7497-0972
DiMaio, Frank
Khare, Sagar D.
Kortemme, Tanja
Labonte, Jason W.
Lindorff-Larsen, Kresten http://orcid.org/0000-0002-4750-6039
Meiler, Jens http://orcid.org/0000-0001-8945-193X
Schief, William http://orcid.org/0000-0002-1120-0150
Schueler-Furman, Ora http://orcid.org/0000-0002-1624-0362
Siegel, Justin B.
Stein, Amelie http://orcid.org/0000-0002-5862-1681
Yarov-Yarovoy, Vladimir http://orcid.org/0000-0002-2325-4834
Kuhlman, Brian http://orcid.org/0000-0003-4907-9699
Leaver-Fay, Andrew http://orcid.org/0000-0003-4609-4340
Gront, Dominik
Gray, Jeffrey J. http://orcid.org/0000-0001-6380-2324
Bonneau, Richard http://orcid.org/0000-0003-4354-7906
Funding for this research was provided by:
Simons Foundation
Article History
Received: 8 April 2021
Accepted: 2 November 2021
First Online: 29 November 2021
Competing interests
: Rosetta software has been licensed to numerous non-profit and for-profit organizations. Rosetta Licensing is managed by UW CoMotion, and royalty proceeds are managed by the RosettaCommons. Under institutional participation agreements between the University of Washington, acting on behalf of the RosettaCommons, their respective institutions may be entitled to a portion of the revenue received on licensing Rosetta software including programs described here. D.B., J.J.G., R.B., O.S.F., D.G., T.K., J.M., and V.Y.Y. are unpaid board members of the RosettaCommons. As members of the Scientific Advisory Board of Cyrus Biotechnology, D.B. and J.J.G. are granted stock options. S.M.L., A.L.L., and D.F. are employed by or have a relationship with Cyrus Biotechnology. Cyrus Biotechnology distributes the Rosetta software, which includes the methods discussed in this study. V.K.M. is a co-founder of and shareholder in Menten Biotechnology Labs, Inc. The content of this manuscript is relevant to work performed at Menten. J.M. is employed by Menten with granted stock options. D.B. is a cofounder of, shareholder in, or advisor to the following companies: ARZEDA, PvP Biologics, Cyrus Biotechnology, Cue Biopharma, Icosavax, Neoleukin Therapeutics, Lyell Immunotherapeutics, Sana Biotechnology, and A-Alpha Bio. CBK is a co-founder and manager of Stealth Biologics, LLC, a biotechnology company. R.B. is executive director of Prescient Design/Genentech, a member of the Roche group. The remaining authors declare no competing interests.