Gamez, Stephanie http://orcid.org/0000-0003-0665-0066
Chaverra-Rodriguez, Duverney http://orcid.org/0000-0001-8068-7436
Buchman, Anna http://orcid.org/0000-0002-8775-6147
Kandul, Nikolay P.
Mendez-Sanchez, Stelia C. http://orcid.org/0000-0002-2402-3632
Bennett, Jared B. http://orcid.org/0000-0003-4718-257X
Sánchez C., Héctor M. http://orcid.org/0000-0001-7378-8853
Yang, Ting http://orcid.org/0000-0001-7201-4231
Antoshechkin, Igor http://orcid.org/0000-0002-9934-3040
Duque, Jonny E. http://orcid.org/0000-0003-2245-0558
Papathanos, Philippos A.
Marshall, John M. http://orcid.org/0000-0003-0603-7341
Akbari, Omar S. http://orcid.org/0000-0002-6853-9884
Funding for this research was provided by:
United States Department of Defense | Defense Advanced Research Projects Agency (HR0011-17-2-0047)
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (R01AI151004)
Article History
Received: 11 August 2021
Accepted: 3 November 2021
First Online: 10 December 2021
Competing interests
: O.S.A. is a founder of Agragene, Inc., and has an equity interest. The terms of this arrangement have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies. S.G. is currently affiliated with Agragene Inc. A.B. is currently affiliated with Verily Life Sciences. All other authors declare no competing interests.
: We have complied with all relevant ethical regulations for animal testing and research and conformed to the UCSD institutionally approved biological use authorization protocol (BUA #R2401).
: All crosses using gene drive genetics were performed in accordance with a protocol approved by the Institutional Biosafety Committee at UCSD, in which full gene drive experiments were performed in a high-security ACL2 barrier facility and split drive experiments were performed in an ACL1 insectary in plastic vials that were autoclaved prior to being discarded, in accordance with currently suggested guidelines for the laboratory confinement of gene drive systems<sup>73</sup><sup>,</sup><sup>74</sup>.