van der Heijden, Michiel S. http://orcid.org/0000-0002-4407-7881
Powles, Thomas http://orcid.org/0000-0001-7760-4724
Petrylak, Daniel
de Wit, Ronald
Necchi, Andrea
Sternberg, Cora N. http://orcid.org/0000-0003-3938-2627
Matsubara, Nobuaki
Nishiyama, Hiroyuki http://orcid.org/0000-0001-7423-596X
Castellano, Daniel
Hussain, Syed A. http://orcid.org/0000-0003-1552-511X
Bamias, Aristotelis http://orcid.org/0000-0002-5996-7262
Gakis, Georgios
Lee, Jae-Lyun
Tagawa, Scott T. http://orcid.org/0000-0003-2777-8587
Vaishampayan, Ulka
Aragon-Ching, Jeanny B. http://orcid.org/0000-0002-6714-141X
Eigl, Bernie J. http://orcid.org/0000-0003-1653-6929
Hozak, Rebecca R.
Rasmussen, Erik R.
Xia, Meng Summer
Rhodes, Ryan
Wijayawardana, Sameera
Bell-McGuinn, Katherine M.
Aggarwal, Amit
Drakaki, Alexandra http://orcid.org/0000-0001-8865-3548
Funding for this research was provided by:
Eli Lilly and Company (N/A)
Article History
Received: 3 February 2021
Accepted: 16 March 2022
First Online: 6 April 2022
Competing interests
: M.S.v.d.H. has received research support from Bristol Myers Squibb, AstraZeneca, Roche, and 4SC; and consultancy fees from BMS, Merck, Sharp & Dhome, Roche, AstraZeneca, Seattle Genetics, Janssen, and Pfizer (all paid to Institute). T.P. reports consulting honoraria from AstraZeneca, BMS, Exelixis, Incyte, Ipsen, Merck, MSD, Novartis, Pfizer, Seattle Genetics, Merck Serono, Astellas, Johnson & Johnson, Eisai, and Roche; grants/funding (to Institution) from AstraZeneca, BMS, Exelixis, Ipsen, Merck, MSD, Novartis, Pfizer, Seattle Genetics, Merck Serono, Astellas, Johnson & Johnson, Eisai, and Roche; and travel expenses from Roche, Pfizer, MSD, AstraZeneca, and Ipsen. D.P. has received consultancy fees from Ada Cap (Advanced Accelerator Applications) Amgen, Astellas, AstraZeneca, Bayer, Bicycle Therapeutics, Boehringer Ingelheim, Bristol Myers Squibb, Clovis Oncology, Eli Lilly and Company, Exelixis, Gilead Sciences, Incyte, Janssen, Mirati, Monopteros, Pfizer, Pharmacyclics, Regeneron, Roche, Seattle Genetics, and Urogen; grant support from Ada Cap (Advanced Accelerator Applications), Agensys Inc., *Astellas, AstraZeneca, *Bayer, BioXcel Therapeutics, Bristol Myers Squibb, Clovis Oncology, Eisai, *Eli Lilly and Company, *Endocyte, Genentech, *Innocrin, MedImmune, Medivation, Merck, Mirati, *Novartis, Pfizer, *Progenics, Replimune, Roche, *Sanofi Aventis, and Seattle Genetics (*denotes study trials have terminated); and ownership interest/investment in Bellicum (sold 7/2020) and Tyme (sold 10/2019). R.d.W. has received consultancy fees from Merck, Sanofi, Astellas, Janssen, Clovis, Orion, and Bayer; speaker fees from Astellas, Sanofi, and Merck; and has received research grants (to Institution) from Sanofi and Bayer. A.N. has a consulting role with Merck, AstraZeneca, Janssen, Incyte, Roche, Rainier Therapeutics, Clovis Oncology, Bayer, Astellas/Seattle Genetics, Ferring, and Immunomedics; has received grant/research support from Merck, Ipsen, and AstraZeneca; and travel expenses/honoraria from Roche, Merck, AstraZeneca, and Janssen. C.N.S. has served in an advisory/consultancy role for Pfizer, MSD, Merck, AstraZeneca, Astellas, Sanofi-Genzyme, Roche-Genentech, Incyte, Medscape, UroToday, and Foundation Medicine. N.M. reports personal fees from Chugai, Janssen, MSD, and Sanofi and grants from Astellas Pharma, Inc., AstraZeneca, Chugai, Eli Lilly and Company, Taiho, Janssen, MSD, Takeda, Amgen, and Pfizer. H.N. reports personal fees from Astellas Pharma, Inc., Chugai, Janssen, Merck, Sharp & Dhome, and Nippon Kayaku and grants from Astellas Pharma, Inc., Ono, and Chugai. S.A.H. has an advisory/consulting role with Roche, MSD, AstraZeneca, BMS, Janssen, Astellas, Bayer, Ipsen, Pfizer, Pierre Fabre, and Sotio and has received research funding from Cancer Research UK, MRC/NIHR, Janssen, and Boehringer Ingelheim. A.B. has an advisory/consulting role with Roche, Pfizer, Bristol Myers Squibb, AstraZeneca, and IPSEN Pharma; receiving honoraria from Bristol Myers Squibb, IPSEN Pharma, and Merck, Sharpe & Dohme and research support from AstraZeneca, Bristol Myers Squibb, Pfizer, IPSEN Steering Committee, and Roche. G.G. has served on an Advisory Board (last 5 years) for Bayer, MSD, Medac, IPSEN Pharma, Merck, LEO Pharma, and Astellas and has acted as an expert for Erbe Elektromedizin, IPSEN Pharma, Roche, Ferring, LEO Pharma, Merck, and Medac. S.T.T. reports research funding (to Institution) from Eli Lilly and Company and Sanofi and honoraria from Sanofi. U.V. reports research support from Astellas, Merck, and Bristol Myers Squibb and consulting and honoraria from AAA Pharmaceutical, Aveo, Bristol Myers Squibb, Bayer, Exelixis, Merck, Pfizer, and Sanofi. J.B.A.-C. serves on the Speakers’ Bureau of Astellas/Seattle Genetics and Bristol Myers Squibb and receives advisory board fees from EMD Serono, Pfizer, Aveo Pharmaceuticals, Immunomedics, AstraZeneca, Exelixis, and Merck. B.J.E. serves in an advisory/consultancy role for Merck, Janssen, AstraZeneca, Roche, Pfizer, EMD Serono, and SEAGEN. R.R.H., E.R.R., M.S.X., and S.W. are employees and shareholders of Eli Lilly and Company. K.M.B.-M. is a shareholder and former employee of Eli Lilly and Company and a shareholder and current employee of AbbVie. A.A. is a shareholder and former employee of Eli Lilly and Company and is currently an employee of Daiichi Sankyo, Inc. (US). A.D. has an advisory/consulting role with AstraZeneca, PACT Pharma, Astellas/Seattle Genetics, Janssen, Nektar, Bristol Myers Squibb, Radmetrix, Merck, Roche/Genentech, Exelixis, and Dyania Health; has received travel reimbursement from Eli Lilly and Company, AstraZeneca, and Seattle Genetics; holds stock and/or other interests in Attica Sciences and ATHOS Therapeutics; and has received research funding (to Institution unless noted otherwise) from AstraZeneca, Genentech/Roche, BMS, Merck Sharp & Dohme, Jounce Therapeutics, Infinity Pharmaceuticals, Seattle Genetics/Astellas, and Kite/Gilead (to A.D.). The disclosures reported herein, for each author, are potential conflicts only on the premise that the companies listed manufacture drugs for cancer treatment. The following authors declare no competing interests: D.C., A.B., J.L.L., R.R.