Donovan-Banfield, I’ah http://orcid.org/0000-0002-5124-2427
Penrice-Randal, Rebekah http://orcid.org/0000-0002-0653-2097
Goldswain, Hannah http://orcid.org/0000-0003-4194-8714
Rzeszutek, Aleksandra M.
Pilgrim, Jack
Bullock, Katie
Saunders, Geoffrey
Northey, Josh
Dong, Xiaofeng
Ryan, Yan http://orcid.org/0000-0002-4708-5350
Reynolds, Helen
Tetlow, Michelle
Walker, Lauren E.
FitzGerald, Richard
Hale, Colin
Lyon, Rebecca
Woods, Christie
Ahmad, Shazaad
Hadjiyiannakis, Dennis
Periselneris, Jimstan
Knox, Emma
Middleton, Calley
Lavelle-Langham, Lara
Shaw, Victoria
Greenhalf, William
Edwards, Thomas http://orcid.org/0000-0003-4058-4461
Lalloo, David G. http://orcid.org/0000-0001-7680-2200
Edwards, Christopher J.
Darby, Alistair C.
Carroll, Miles W.
Griffiths, Gareth
Khoo, Saye H.
Hiscox, Julian A. http://orcid.org/0000-0002-6582-0275
Fletcher, Thomas
Funding for this research was provided by:
Cancer Research UK (C18616/A25153)
U.S. Department of Health & Human Services | U.S. Food and Drug Administration (75F40120C00085, 75F40120C00085, 75F40120C00085, 75F40120C00085)
U.S. Department of Health & Human Services | U.S. Food and Drug Administration
RCUK | Medical Research Council (MR/V028391/1, MR/W005611/1)
Wellcome Trust (221590/Z/20/Z)
U.S. Department of Health & Human Services | U.S. Food and Drug Administration
DH | National Institute for Health Research (200907, 200907)
U.S. Department of Health & Human Services | U.S. Food and Drug Administration
Article History
Received: 26 September 2022
Accepted: 9 November 2022
First Online: 26 November 2022
Competing interests
: SHK has received research funding from ViiV Healthcare and Merck for the Liverpool HIV Drug Interactions programme and for unrelated clinical studies. GG has received funding from Janssen-Cilag, AstraZeneca, Novartis, Astex, Roche, Heartflow, Celldex, BMS, BionTech, Cancer Research UK, the NIHR, the British Lung Foundation, Unitaid, and GSK for unrelated academic clinical trials and programme funding. WG has received funding from the Wellcome Trust. JP (Periselneris) has received honoraria for lectures from Gilead and London International Patient Services UK. JAH, ACD, MWC and TF have received research funding from the US Food and Drug Administration. TE has received unrelated research funding from the Medical Research Council, the Wellcome Trust, and Bloomsbury SET and travel grants from the European Society of Clinical Microbiology and Infectious Diseases. All other authors declare no competing interests.
: The study protocol was reviewed and approved by the UK Medicines and Healthcare product Regulatory Agency (MHRA) (EudraCT 2020-001860-27) and West Midlands Edgbaston Research Ethics Committee (20/WM/0136).
: All participants provided written informed consent before enrolment.