Brase, Logan http://orcid.org/0000-0002-7175-3208
You, Shih-Feng
D’Oliveira Albanus, Ricardo http://orcid.org/0000-0003-3651-0136
Del-Aguila, Jorge L. http://orcid.org/0000-0002-6364-8707
Dai, Yaoyi http://orcid.org/0000-0003-1908-2539
Novotny, Brenna C. http://orcid.org/0000-0003-4732-1736
Soriano-Tarraga, Carolina
Dykstra, Taitea http://orcid.org/0000-0001-7756-809X
Fernandez, Maria Victoria http://orcid.org/0000-0002-9669-5147
Budde, John P. http://orcid.org/0000-0001-7778-7276
Bergmann, Kristy
Morris, John C.
Bateman, Randall J. http://orcid.org/0000-0002-7729-1702
Perrin, Richard J. http://orcid.org/0000-0002-3443-7716
McDade, Eric http://orcid.org/0000-0002-6764-3866
Xiong, Chengjie
Goate, Alison M. http://orcid.org/0000-0002-0576-2472
Farlow, Martin
Sutherland, Greg T. http://orcid.org/0000-0003-2493-9736
Kipnis, Jonathan http://orcid.org/0000-0002-3714-517X
Karch, Celeste M. http://orcid.org/0000-0002-6854-5547
Benitez, Bruno A.
Harari, Oscar http://orcid.org/0000-0002-2635-6975
,
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01AG057777, R56AG067764, U01AG072464, R01AG074012, P30AG066444, P01AGO26276, U19AG032438, P01AG003991)
U.S. Department of Health & Human Services | NIH | National Institute on Aging
U.S. Department of Health & Human Services | NIH | National Institute on Aging
U.S. Department of Health & Human Services | NIH | National Institute on Aging
U.S. Department of Health & Human Services | NIH | National Institute on Aging
U.S. Department of Health & Human Services | NIH | National Institute on Aging
U.S. Department of Health & Human Services | NIH | National Institute on Aging
U.S. Department of Health & Human Services | NIH | National Institute on Aging
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (RFNS110809, R01AG062734)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke
BrightFocus Foundation
Chan Zuckerberg Initiative
Article History
Received: 4 October 2022
Accepted: 15 March 2023
First Online: 21 April 2023
Competing interests
: J.C.M. is a consultant for the Barcelona Brain Research Center (BBRC) and the TS Srinivasan Advisory Board. J.C.M. is an advisory board member for the Cure Alzheimer’s Fund Research Strategy Council. R.J.B. maintains an equity ownership interest and is a member of the advisory board of C2N Diagnostics. Unrelated to this article, R.J.B. serves as the principal investigator of the DIAN-TU, which the Alzheimer’s Association supports, GHR Foundation, an anonymous organization, and the DIAN-TU Pharma Consortium (Active: Eli Lilly and Company/Avid Radiopharmaceuticals, F. Hoffman-La Roche/Genentech, Biogen, Eisai, and Janssen. Previous: Abbvie, Amgen, AstraZeneca, Forum, Mithridion, Novartis, Pfizer, Sanofi, and United Neuroscience). In addition, in-kind support has been received from CogState and Signant Health. Unrelated to this article, R.J.B. has submitted the US nonprovisional patent application “Methods for Measuring the Metabolism of CNS Derived Biomolecules in Vivo” and provisional patent application “Plasma Based Methods for Detecting CNS Amyloid Deposition.” E.M. receives research support from the NIA, Hoffman-La Roche, and Eli Lilly, is a member of advisory boards for Eli Lilly, Alector, and the NIA, and holds a leadership role in Fondation Alzheimer and Alzamend. C.X. is a consultant for DIADEM and a member of the advisory board for the University of Wisconsin ADRC. A.G. receives royalties from Athena Diagnostics and Taconic Biosciences, is a consultant for Genentech SAB and AbbVie and holds stock or stock options in Cognition Therapeutics and Denali Therapeutics. M.F. receives research support from Eli Lilly and Company, Hoffmann-La Roche, Avanir, Biogen, Cognition Therapies, Green Valley, Otsuka, Neurotrope Biosciences, AZTherapies, Athira, Ionis, and Lexeo, and is a member of advisory boards for Oligomerik and T3D. The remaining authors declare no competing interests.