Tan, Timothy J. C. http://orcid.org/0000-0001-5337-5357
Mou, Zongjun
Lei, Ruipeng http://orcid.org/0000-0002-4652-3400
Ouyang, Wenhao O.
Yuan, Meng http://orcid.org/0000-0001-9754-4503
Song, Ge http://orcid.org/0000-0001-7306-3510
Andrabi, Raiees http://orcid.org/0000-0001-8837-7520
Wilson, Ian A. http://orcid.org/0000-0002-6469-2419
Kieffer, Collin http://orcid.org/0000-0001-9051-3819
Dai, Xinghong http://orcid.org/0000-0002-4102-3175
Matreyek, Kenneth A. http://orcid.org/0000-0001-9149-551X
Wu, Nicholas C. http://orcid.org/0000-0002-9078-6697
Funding for this research was provided by:
Bill and Melinda Gates Foundation (INV-004923)
U.S. Department of Health & Human Services | National Institutes of Health (R35 GM142886, R01 AI167910, DP2 AT011966)
U.S. Department of Health & Human Services | National Institutes of Health
U.S. Department of Health & Human Services | National Institutes of Health
Article History
Received: 20 October 2022
Accepted: 31 March 2023
First Online: 10 April 2023
Competing interests
: N.C.W., K.A.M. and T.J.C.T. have filed a provisional patent application (IL0042US.L) with the University of Illinois covering the deep mutational scanning-based method to identify prefusion-stabilizing mutations for vaccine design and SARS-CoV-2 spike with the K986P/V987P/D994Q mutations described in this article. N.C.W. serves as a consultant for HeliXon. The remaining authors declare no other competing interests.