Santos, Mark F. http://orcid.org/0000-0002-6347-8576
Rappa, Germana
Karbanová, Jana http://orcid.org/0000-0001-7687-0983
Diana, Patrizia
Cirrincione, Girolamo http://orcid.org/0000-0003-0468-625X
Carbone, Daniela http://orcid.org/0000-0001-5969-7023
Manna, David
Aalam, Feryal
Wang, David
Vanier, Cheryl http://orcid.org/0000-0003-0497-6150
Corbeil, Denis http://orcid.org/0000-0003-1181-3659
Lorico, Aurelio
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | Center for Scientific Review (1R15CA252990)
Article History
Received: 27 May 2022
Accepted: 19 July 2023
First Online: 10 August 2023
Competing interests
: The United Kingdom patent application GB2598624A (applicants: M.F.S., G.R., P.D., G.C., A.L., and Technische Universität Dresden; inventors: M.F.S., G.R., P.D., G.C., D.C., and A.L.), European patent application EP3864409A1 (applicants: M.F.S., G.R., A.L. and Technische Universität Dresden; inventors; M.F.S., G.R., D.C. and A.L.) and United States provisional patent number US20210353616A1 (applicants: M.F.S., G.R., A.L. and Technische Universität Dresden; inventors: M.F.S., G.R., D.C., and A.L.) are pending. The patent EP3864409A1/US20210353616A1 is entitled: Inhibition of a tripartite VOR protein complex in multicellular organisms. The patent GB2598624A is entitled: Use of triazole analogues for inhibition of a tripartite VOR protein complex in multicellular organism. These patents are related to the use of itraconazole and triazole analogues to inhibit the VOR protein complex, which prevents the nuclear transfer of materials transported by extracellular particles (e.g., extracellular vesicles and viruses). The authors declare no other competing interests.