Okamoto, Yuji
Hirano, Mitsuhito
Morino, Kai
Kajita, Masashi K. http://orcid.org/0000-0002-2939-2058
Nakaoka, Shinji http://orcid.org/0000-0002-3277-9552
Tsuda, Mayuko
Sugimoto, Kei-ji
Tamaki, Shigehisa
Hisatake, Junichi
Yokoyama, Hisayuki http://orcid.org/0000-0001-7658-0687
Igarashi, Tadahiko
Shinagawa, Atsushi
Sugawara, Takeaki
Hara, Satoru
Fujikawa, Kazuhisa
Shimizu, Seiichi
Yujiri, Toshiaki http://orcid.org/0000-0001-6838-3456
Wakita, Hisashi
Nishiwaki, Kaichi
Tojo, Arinobu
Aihara, Kazuyuki
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (JP15H05707, JP15H05707, JP15H05707, JP15H05707)
MEXT | JST | Precursory Research for Embryonic Science and Technology (JPMJPR16E9)
MEXT | Japan Science and Technology Agency (JPMJMS2021)
Japan Agency for Medical Research and Development (JP22dm0307009)
Institute of AI and Beyond of The University of Tokyo
Article History
Received: 22 February 2022
Accepted: 16 September 2022
First Online: 13 October 2022
Competing interests
: K.M. reports a grant from NEC outside the submitted work. S.N. reports a grant from Morinaga Milk Industry Co., Ltd. outside the submitted work. K.N. received a grant for this work from Novartis Pharma K.K. and reports grants from Zenyaku Kogyo Company, Ltd., Asahi Kasei Pharma, and Taiho Pharmaceutical Co., Ltd.; grants and personal fees from Chugai Pharmaceutical, Kyowa Hakko Kirin Co., Ltd., Nippon Shinyaku Co., Ltd., Mochida Pharmaceutical Co., Ltd., Ono Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co., Ltd., and Sumitomo Dainippon Pharma Co., Ltd.; and personal fees from Pfizer, Otsuka Pharmaceutical Co., Ltd., Janssen Pharmaceutical K.K., Eisai Co., Ltd., and Celgene K.K. outside of the submitted work. H.Y. reports grants from Celgene K.K. and Astellas Pharma Inc. outside the submitted work. A.T. reports personal fees from Sysmex, Otsuka Pharmaceutical Co., Ltd., Bristol-Myers Squib, and Takeda Pharmaceutical Co., Ltd., Daiichi-Sankyo and grants and personal fees from Pfizer, and Chugai Pharmaceutical outside the submitted work. K.A. reports a grant and personal fees from KKE, a grant and personal fees from NEC, a grant from Sysmex, a personal fee from Novo Nordisk Japan, and a grant and personal fees from Toyota Central R&D Labs. outside the submitted work. Y.O. had worked at Sysmex Co., but the entire results of this paper are totally independent from his past job in Sysmex Co.. The other authors have nothing to disclose.
: This research has been approved by the Institutional Review Boards at The University of Tokyo, at The Institute of Medical Science, The University of Tokyo (IMSUT), at Kyushu University, at University of Fukui, and at Hokkaido University, and conducted in accordance with the ethical guidelines for medical and health research involving human subjects. This research also adhered to the ethical principles of the Declaration of Helsinki. All patients provided written informed consent for participation prior to initiation of any study procedures of the N-road study <sup>17</sup>.