Article History
Received: 21 March 2019
Accepted: 12 December 2019
First Online: 3 February 2020
Competing interests
: A.A.S. declares inventorship on the following published patents, applied for by the Broad Institute of MIT and Harvard and the Massachusetts Institute of Technology: WO2018035250A1 on methods for bioinformatic discovery of class 2 CRISPR–Cas systems; WO2017070605 on systems, methods, and compositions for targeting nucleic acids with type VI-B CRISPR–Cas systems. G.W.Y is co-founder, member of the Board of Directors, on the SAB, equity holder, and paid consultant for Locana and Eclipse BioInnovations. G.W.Y. is a Distinguished Visiting Professor at the National University of Singapore. The terms of this arrangement have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies.