Cruz, Michelle A.
Bohinc, Dillon
Andraska, Elizabeth A. http://orcid.org/0000-0001-6536-070X
Alvikas, Jurgis
Raghunathan, Shruti
Masters, Nicole A.
van Kleef, Nadine D. http://orcid.org/0000-0001-7162-9277
Bane, Kara L.
Hart, Kathryn
Medrow, Kathryn
Sun, Michael
Liu, Haitao http://orcid.org/0000-0002-3757-779X
Haldeman, Shannon
Banerjee, Ankush
Lessieur, Emma M. http://orcid.org/0000-0001-9120-0291
Hageman, Kara
Gandhi, Agharnan http://orcid.org/0000-0001-9772-6841
de la Fuente, Maria
Nieman, Marvin T.
Kern, Timothy S.
Maas, Coen
de Maat, Steven
Neeves, Keith B.
Neal, Matthew D. http://orcid.org/0000-0001-8931-6236
Sen Gupta, Anirban http://orcid.org/0000-0002-5773-0667
Stavrou, Evi X. http://orcid.org/0000-0002-6075-7609
Article History
Received: 21 February 2021
Accepted: 24 May 2022
First Online: 18 July 2022
Competing interests
: A.S.G. is a coinventor on issued patent US 9107845 (Synthetic Platelets) that is licensed from Case Western Reserve University to Haima Therapeutics. A.S.G. is a cofounder and equity stakeholder of Haima Therapeutics. The patent is on the design of a heteromultivalent NP system that can mimic the haemostatic functions of a platelet. A.S.G. is also a coinventor on issued patent US 9107963 (Heteromultivalent Nanoparticle Compositions). The patent is on the design of heteromultivalently decorated NPs for clot targeting. Although the specific NP systems described in these two patents have no direct relevance to any specific aspect of the manuscript, the context of ‘heteromultivalent NP design’ is a central aspect of the NT-NP and PNT-NP systems described in the manuscript. M.D.N. serves on the scientific advisory board of Haima Therapeutics and holds equity stake. E.X.S. is coinventor of intellectual property that has been licensed by Case Western Reserve University to XaTek and receives royalties. The patent PCT/US2017/013797 is on dielectric spectroscopy for whole blood assessment of haemostasis. This patent bears no relevance to any of the work presented in the manuscript. C.M. has been a speaker for Shire-Takeda. C.M. and S.d.M. are cofounders of TargED BV, a biotech spinout company of University Medical Center Utrecht (based upon the WO2019185723 A1 patent). C.M. and S.d.M. participate in revenue sharing as inventors through the commercialization arm of the University Medical Center Utrecht. The remaining authors declare no competing interests.
Free to read: This content has been made available to all.