Kadosh, Eliran
Snir-Alkalay, Irit
Venkatachalam, Avanthika
May, Shahaf
Lasry, Audrey
Elyada, Ela
Zinger, Adar
Shaham, Maya
Vaalani, Gitit
Mernberger, Marco
Stiewe, Thorsten http://orcid.org/0000-0003-0134-7826
Pikarsky, Eli
Oren, Moshe
Ben-Neriah, Yinon
Article History
Received: 2 April 2019
Accepted: 1 May 2020
First Online: 29 July 2020
Competing interests
: A US provisional patent application (no. 62/987,058) entitled ‘A method for the diagnosis and treatment of cancer’ was filed on 9 March 2020. The inventors are Y.B.-N., E.K. and I.S.-A. The invention is based on the finding that gut microbiota, in particular polyphenol-producing microbiota, promote colorectal cancer and have a pro-tumorigenic effect both in vitro and in vivo. The invention concerns a method for the prevention and therapy of cancer in patients who have a tumour with an oncogenic p53 mutation. The method involves therapy with agents that reduce the levels of polyphenols, in particular the levels of gallic acid in the gut.