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Article History
Received: 15 December 2021
Accepted: 29 July 2022
First Online: 30 September 2022
Change Date: 14 November 2022
Change Type: Correction
Change Details: A Correction to this paper has been published:
Change Details: https://doi.org/10.1038/s41586-022-05492-5
Competing interests
: C.D.A. has received sponsored research support from Bayer, and has consulted for ApoPharma; T. Konuma is an employee of JAPAN TOBACCO; M. E. reports grants from Bayer and fees paid to the Charité from Abbot, AstraZeneca, Bayer, Boehringer Ingelheim, BMS, Daiichi Sankyo, Amgen, GSK, Sanofi, Covidien, Novartis and Pfizer, all outside the submitted work; B.M.P. serves on the steering committee of the Yale Open Data Access Project funded by Johnson & Johnson; P.A. works with Fondation Alzheimer (nonprofit foundation) and Genoscreen (biotech company); H.L.L.’s participation in this project was part of a competitive contract awarded to Data Tecnica International by the National Institutes of Health to support open science research; M.A.N.’s participation in this project was part of a competitive contract awarded to Data Tecnica International by the National Institutes of Health to support open science research, he also currently serves on the scientific advisory board for Clover Therapeutics and is an advisor to Neuron23; N.A.M. declares institutional research grants to the TIMI Study Group at Brigham and Women’s Hospital from Amgen, Pfizer, Ionis, Novartis, AstraZeneca and NIH. The TIMI Study Group has received institutional research grant support through Brigham and Women’s Hospital from Abbott, Amgen, Anthos Therapeutics, ARCA Biopharma, AstraZeneca, Daiichi-Sankyo, Eisai, Intarcia, Ionis Pharmaceuticals, MedImmune, Merck, Novartis, Pfizer, Regeneron Pharmaceuticals, Roche, The Medicines Company, Zora Biosciences, Janssen Research and Development, Siemens Healthcare Diagnostics and Softcell Medical; F.K.K. declares that the TIMI Study Group has received institutional research grant support through Brigham and Women’s Hospital from Abbott, Amgen, Anthos Therapeutics, ARCA Biopharma, AstraZeneca, Daiichi-Sankyo, Eisai, Intarcia, Ionis Pharmaceuticals, MedImmune, Merck, Novartis, Pfizer, Regeneron Pharmaceuticals, Roche, The Medicines Company and Zora Biosciences; M.S.S. has consultancies with Althera, Amgen, Anthos Therapeutics, AstraZeneca, Beren Therapeutics, Bristol-Myers Squibb, DalCor, Dr. Reddy’s Laboratories, Fibrogen, IFM Therapeutics, Intarcia, Merck, Moderna, Novo Nordisk and Silence Therapeutics, and research grant support through Brigham and Women’s Hospital from Abbott, Amgen, Anthos Therapeutics, AstraZeneca, Bayer, Daiichi-Sankyo, Eisai, Intarcia, Ionis, Medicines Company, MedImmune, Merck, Novartis, Pfizer, Quark Pharmaceuticals; C.T.R. has consultancies with Anthos, Bayer, Bristol Myers Squibb, Boehringer Ingelheim, Daiichi Sankyo, Janssen and Pfizer, institutional research grant to the TIMI Study Group at Brigham and Women’s Hospital from Anthos, AstraZeneca, Boehringer Ingelheim, Daiichi Sankyo, Janssen, National Institutes of Health and Novartis, and consultancies with Anthos, Bayer, Bristol Myers Squibb, Boehringer Ingelheim, Daiichi Sankyo, Janssen and Pfizer. T.H. receives personal fees from Genome Analytics Japan; J.C.H. is supported by a personal fellowship from the British Heart Foundation (FS/14/55/30806), and acknowledges additional support from the Nuffield Department of Population Health (NDPH), University of Oxford, the British Heart Foundation Centre for Research Excellence, Oxford, and the Oxford Biomedical Research Centre. J.C.H. holds steering committee and Data and Safety Monitoring Board (DSMB) positions for various cardiovascular randomized controlled trials, and is a principal investigator/co-principal investigator of research grants from industry related to cardiovascular clinical trials and observational studies that are governed by University of Oxford contracts that protect personal independence. NDP.H also has a staff policy of not taking personal payments from industry (further details can be found online; ExternalRef removed); S.S. has consultancies with Biogen; P.U.H. reports grants from German Ministry of Research and Education, during the conduct of the study, research grants from the German Ministry of Research and Education, European Union, Charité–Universitätsmedizin Berlin, Berlin Chamber of Physicians, German Parkinson Society, University Hospital Würzburg, Robert Koch Institute, German Heart Foundation, Federal Joint Committee (G-BA) within the Innovationfond, German Research Foundation, Bavarian State (ministry for science and the arts), German Cancer Aid, Charité–Universitätsmedizin Berlin (within Mondafis; supported by an unrestricted research grant to the Charité from Bayer), University Göttingen (within FIND-AF randomized; supported by an unrestricted research grant to the University Göttingen from Boehringer- Ingelheim), University Hospital Heidelberg (within RASUNOA-prime; supported by an unrestricted research grant to the University Hospital Heidelberg from Bayer, BMS, Boehringer-Ingelheim and Daiichi Sankyo), outside the submitted work; K.G.H. reports a study grant by Bayer, lecture fees/advisory board fees from Abbott, Alexion, AMARIN, AstraZeneca, Bayer, Biotronik, Boehringer Ingelheim, Bristol-Myers-Squibb, Daiichi Sankyo, Edwards Lifesciences, Medtronic, Pfizer, Premier Research, SUN Pharma and W. L. Gore & Associates; H.J.G. has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care; J.M.M.H. is full time employee of Novo Nordisk; E.Y.-D. is full-time employee of Novo Nordisk. S. Damrauer receives research support from RenalytixAI and personal consulting fees from Calico Labs, outside the scope of the current research. H.B. reports grants from AstraZeneca, AstraZeneca Korea, Bayer Korea, Boehringer Ingelheim Korea, Boryung Pharmaceutical, Bristol Myers Squibb, Bristol Myers Squibb Korea, Chong Gun Dang Pharmaceutical, Daiichi Sankyo, Daiichi Sankyo Korea, Dong-A ST, Esai, Jeil Pharmaceutical, JLK, Korean Drug, SAMJIN Pharm., Servier Korea, Shinpoong Pharm., Shire International and Yuhan Corporation, and personal fees from Amgen Korea, Esai Korea, Otsuka Korea, Takeda Korea and Viatris Korea outside the submitted work. C.C. has received research support from GSK. The funders of the study had no role in the collection, analysis or interpretation of data, in the writing of the report or in the decision to submit the paper for publication. C.C. is a member of the advisory board of Vivid genetics; F.A.M. is supported by the German Research Foundation (Deutsche Forschungsgemeinschaft (DFG) within the UNION-CVD Clinician-Scientist Programme (project number 413657723) and has been previously supported by a MD/PhD Fellowship of the Interdisciplinary Center for Clinical Research, University Hospital Würzburg. A. Mishra, R.M., T.J., S.N., D.C.P., M. Koido, Q.L.G., M. Shi, Y.H., M.K.G., I.C., K.K., Yi-Ching Liaw, F.C.V., K. Lin., B.S.W., V. Srinivasasainagendra, L.P., G.C., M.R.C., L.T., R.A., G.V.R., N.H., Y.H.J., J.Q.T., V.A., J.C., M.N., C.Y., E.Y., M.J.K., A.J.L., R.L., T.A., N.D.A., M.K.B., T.M.B., D.A.B., J.C.B., C.B., S.B., A.C., P.M.R., K. Cho, Z.C., J.W.C., P.L.d., R.d.C., M.E., L.E.F., M.I.G., N.C.G., V.G., J. Hata, J. He., A.K.H., Y. Ho., A.S.H., H.I.H., M.I., M.A.J., C.E.J., C.J., M. Kamouchi, K.L.K., T. Kitazono, S.J.K., A.K., P.L., L.J.L., K. Lee, K. Lepik, J.L., L.L., A. Manichaikul, H.S.M., T. Meitinger, B.D.M., T. Morisaki, T.H.M., B.G.N., M.J.O., Y.O., N.C.O., B.O., A.P., S.S.R., J.R., M.S.S., R.L.S., D. Saleheen, E.C.S., V. Salomaa, M. Sargurupremraj, M. Sasaki, C.L.S., C.O.S., A.S., N.L.S., K.S., Y.S., Y.V.S., K.T., S. Tiedt, T.T., N.P.T., H.K.T., D.T., S. Trompet, A.M.T., A.T., M.v.V., R.V., S.S.V., K.L.W., P.W., D.W., P.W.W., H.X., Q.Y., K.Y., I.Y.M., C.G., T.N., J.W.J., I.L.R., D. Strbian, Y.J.K., P.C., E.M., M.R.I., H.A., S.W., K. Christensen, M.A.I., T.R., B.B.W., G.M.L., M.R., E.M.S., J.K., P.H.F., R.Z., K.P., R.F., F.d.L., T.L., Y.M.R., W.T.L., K.J.J., L.B., G.P., D.I.C., J.I.R., J.Z., T.J.N., M.F., Yung-Po Liaw, I.F., R.G.W., M.O.O., J.E.H., L.M., Y.K., M.D. and S. Debette declare no competing interests.