Replogle, Joseph M. http://orcid.org/0000-0003-1832-919X
Norman, Thomas M.
Xu, Albert http://orcid.org/0000-0001-5938-561X
Hussmann, Jeffrey A. http://orcid.org/0000-0002-7778-9893
Chen, Jin
Cogan, J. Zachery
Meer, Elliott J.
Terry, Jessica M.
Riordan, Daniel P.
Srinivas, Niranjan
Fiddes, Ian T.
Arthur, Joseph G.
Alvarado, Luigi J. http://orcid.org/0000-0002-7448-5384
Pfeiffer, Katherine A.
Mikkelsen, Tarjei S. http://orcid.org/0000-0002-8133-3135
Weissman, Jonathan S. http://orcid.org/0000-0003-2445-670X
Adamson, Britt http://orcid.org/0000-0002-9451-5819
Funding for this research was provided by:
U.S. Department of Health & Human Services | National Institutes of Health (F31 NS115380, GM134154, P50 GM102706, U01 CA168370, R01 DA036858, RM1HG009490)
Damon Runyon Cancer Research Foundation (DRG-[2211-15], DRG-2262-16)
Howard Hughes Medical Institute
Jane Coffin Childs Memorial Fund for Medical Research
10x Genomics
United States Department of Defense | Defense Advanced Research Projects Agency (HR0011-19-2-0007)
Chan Zuckerberg Initiative
Princeton University
Article History
Received: 20 December 2018
Accepted: 26 February 2020
First Online: 30 March 2020
Competing interests
: 10x Genomics was involved in producing this work. I.T.F., J.G.A., L.J.A., K.A.P., E.J.M., J.M.T., D.P.R., N.S. and T.S.M. are employees of 10x Genomics. The Regents of the University of California with T.M.N., J.S.W. and B.A. as inventors have filed patent applications related to CRISPRi/a screening, Perturb-seq and GI mapping. J.S.W. consults for and holds equity in KSQ Therapeutics, Maze Therapeutics and Tenaya Therapeutics; is a venture partner at 5AM Ventures and is a member of the Amgen Scientific Advisory Board. J.M.R. and T.M.N. consult for Maze Therapeutics. B.A. is a member of a ThinkLab Advisory Board for and holds equity in Celsius Therapeutics.