Grünewald, Julian http://orcid.org/0000-0001-7537-7505
Miller, Bret R.
Szalay, Regan N. http://orcid.org/0000-0002-5438-1596
Cabeceiras, Peter K.
Woodilla, Christopher J.
Holtz, Eliza Jane B.
Petri, Karl http://orcid.org/0000-0002-9624-3976
Joung, J. Keith http://orcid.org/0000-0001-5630-5645
Funding for this research was provided by:
Deutsche Forschungsgemeinschaft (416375182, 417577129)
U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (RM1 HG009490)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R35 GM118158)
Article History
Received: 13 September 2021
Accepted: 15 August 2022
First Online: 26 September 2022
Competing interests
: J.K.J. and two other investigators who work on the National Institutes of Health award supporting this research, but are not authors on this publication, are co-founders of and have a financial interest in SeQure Dx, Inc., a company developing technologies for gene editing target profiling. J.K.J. also has, or had during the course of this research, financial interests in several companies developing gene editing technology: Beam Therapeutics, Blink Therapeutics, Chroma Medicine, Editas Medicine, EpiLogic Therapeutics, Excelsior Genomics, Hera Biolabs, Monitor Biotechnologies, Nvelop Therapeutics (f/k/a ETx, Inc.), Pairwise Plants, Poseida Therapeutics and Verve Therapeutics. J.K.J.ʼs interests were reviewed and are managed by Massachusetts General Hospital and Mass General Brigham in accordance with their conflict of interest policies. J.K.J. is a co-inventor on various patents and patent applications that describe gene editing and epigenetic editing technologies. K.P. has a financial interest in SeQure Dx, Inc. K.P.ʼs interests and relationships have been disclosed to Massachusetts General Hospital and Mass General Brigham in accordance with their conflict of interest policies. P.K.C. is a paid consultant to and has financial interests in Nvelop Therapeutics (f/k/a ETx, Inc.). J.G., B.R.M. and J.K.J. are co-inventors on a patent application that has been filed by Mass General Brigham/Massachusetts General Hospital on engineered bipartite PE architectures, reduced size PEs and non-MMLV-RT PE architectures.