Moravec, Ziva http://orcid.org/0009-0001-4351-5317
Zhao, Yue
Voogd, Rhianne
Cook, Danielle R. http://orcid.org/0009-0003-1958-8983
Kinrot, Seon http://orcid.org/0000-0001-5614-0983
Capra, Benjamin
Yang, Haiyan
Raud, Brenda
Ou, Jiayu
Xuan, Jiekun
Wei, Teng
Ren, Lili
Hu, Dandan
Wang, Jun
Haanen, John B.A.G.
Schumacher, Ton N. http://orcid.org/0000-0003-0517-8804
Chen, Xi http://orcid.org/0000-0001-6394-9967
Porter, Ely http://orcid.org/0000-0001-5670-2317
Scheper, Wouter http://orcid.org/0000-0003-1555-587X
Funding for this research was provided by:
KWF Kankerbestrijding (2020-1/12977)
ZonMw (446002001, 446002001)
The V Foundation Mark Foundation ASPIRE award Melanoma Research Alliance Young Investigator award
NWO Stevin Prize Louis-Jeantet Prize
Article History
Received: 26 May 2023
Accepted: 18 March 2024
First Online: 23 April 2024
Competing interests
: D.R.C., Y.Z., B.C., S.K., H.Y., J.O., J.X. and E.P. are employees and stock option holders of RootPath, Inc. or its affiliates. X.C. is a director and shareholder of RootPath, Inc. or its affiliates. J.W. is a paid consultant for RootPath Genomics, Bristol Myers Squibb (Relatlimab Advisory Council) and Hanmi Pharmaceutical and is a founder and equity holder of and a consultant to Remunix, Inc. J.B.A.G.H. is an advisor to Achilles Therapeutics, BioNTech, Instil Bio, Neogene Therapeutics, PokeAcell, Scenic Biotech, T-Knife and Third Rock Ventures; is a recipient of research grant support from BioNTech; and is a stock option holder of Neogene Therapeutics. T.N.S. serves as an advisor for Allogene Therapeutics, Merus, Neogene Therapeutics and Scenic Biotech and is a stockholder in Allogene Therapeutics, Cell Control, Celsius, Merus and Scenic Biotech. T.N.S. is also a venture partner at Third Rock Ventures, all outside the submitted work. W.S. is an advisor to BD Biosciences and Lumicks. The TCR library synthesis method is described in patent application WO2020206238A2, assigned to a subsidiary of RootPath, Inc. (X.C. and E.P.). The other authors declare no competing interests.