Zheng, Jie http://orcid.org/0000-0002-6623-6839
Haberland, Valeriia http://orcid.org/0000-0002-3874-0683
Baird, Denis
Walker, Venexia
Haycock, Philip C.
Hurle, Mark R.
Gutteridge, Alex
Erola, Pau
Liu, Yi
Luo, Shan
Robinson, Jamie http://orcid.org/0000-0001-8721-6514
Richardson, Tom G. http://orcid.org/0000-0002-7918-2040
Staley, James R.
Elsworth, Benjamin http://orcid.org/0000-0001-7328-4233
Burgess, Stephen
Sun, Benjamin B. http://orcid.org/0000-0001-6347-2281
Danesh, John
Runz, Heiko
Maranville, Joseph C.
Martin, Hannah M.
Yarmolinsky, James
Laurin, Charles
Holmes, Michael V.
Liu, Jimmy Z.
Estrada, Karol
Santos, Rita
McCarthy, Linda
Waterworth, Dawn
Nelson, Matthew R.
Smith, George Davey http://orcid.org/0000-0002-1407-8314
Butterworth, Adam S. http://orcid.org/0000-0002-6915-9015
Hemani, Gibran http://orcid.org/0000-0003-0920-1055
Scott, Robert A. http://orcid.org/0000-0003-3634-3016
Gaunt, Tom R. http://orcid.org/0000-0003-0924-3247
Funding for this research was provided by:
RCUK | Medical Research Council (MC_UU_00011/4, MC_UU_00011/4, MC_UU_00011/4, MC_UU_00011/1, MC_UU_00011/4, MC_UU_00011/1, MC_UU_00011/4)
Cancer Research UK (C52724/A20138, C18281/A19169)
British Heart Foundation (FS/18/23/33512)
Wellcome Trust (208806/Z/17/Z)
Article History
Received: 8 April 2019
Accepted: 24 July 2020
First Online: 7 September 2020
Competing interests
: A.G., L.M., M.R.H., D.W., M.R.N., R.S. and R.A.S. are employees and shareholders in GlaxoSmithKline. H.R., J.Z.L. and K.E. are employees and shareholders in Biogen. J.Z. and V.H. are employed on a grant funded by GlaxoSmithKline. D.B. is employed on a grant funded by Biogen. T.R.G., G.H. and G.D.S. receive funding from GlaxoSmithKline and Biogen for the work described here. A.S.B. has received grants from Merck, Novartis, Biogen, Pfizer and AstraZeneca. M.V.H. has collaborated with Boehringer Ingelheim in research and, in accordance with the policy of the Clinical Trial Service Unit and Epidemiological Studies Unit (University of Oxford), did not accept any personal payment. This work was supported by Health Data Research UK, which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), the British Heart Foundation and the Wellcome Trust.