Pirruccello, James P. http://orcid.org/0000-0001-6088-4037
Chaffin, Mark D. http://orcid.org/0000-0002-1234-5562
Chou, Elizabeth L. http://orcid.org/0000-0002-0997-6785
Fleming, Stephen J. http://orcid.org/0000-0002-1885-4405
Lin, Honghuang http://orcid.org/0000-0003-3043-3942
Nekoui, Mahan http://orcid.org/0000-0001-7466-4801
Khurshid, Shaan
Friedman, Samuel F.
Bick, Alexander G.
Arduini, Alessandro
Weng, Lu-Chen http://orcid.org/0000-0003-1475-4930
Choi, Seung Hoan http://orcid.org/0000-0002-2797-3190
Akkad, Amer-Denis
Batra, Puneet http://orcid.org/0000-0001-6822-0593
Tucker, Nathan R.
Hall, Amelia W. http://orcid.org/0000-0002-7915-0313
Roselli, Carolina http://orcid.org/0000-0001-5267-6756
Benjamin, Emelia J. http://orcid.org/0000-0003-4076-2336
Vellarikkal, Shamsudheen K. http://orcid.org/0000-0002-6384-2948
Gupta, Rajat M.
Stegmann, Christian M.
Juric, Dejan
Stone, James R.
Vasan, Ramachandran S. http://orcid.org/0000-0001-7357-5970
Ho, Jennifer E.
Hoffmann, Udo
Lubitz, Steven A. http://orcid.org/0000-0002-9599-4866
Philippakis, Anthony A.
Lindsay, Mark E. http://orcid.org/0000-0001-6724-7938
Ellinor, Patrick T. http://orcid.org/0000-0002-2067-0533
Funding for this research was provided by:
Fondation Leducq (14CVD01)
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (1RO1HL092577, R01HL128914, K24HL105780, T32HL007208, T32HL007208, 5K01HL140187, R01HL128914, 2R01HL092577, 1R01HL141434, R01HL134893, R01HL140224, 1R01HL139731)
American Heart Association (Strategically Focused Research Networks, 18SFRN34110082, 18SFRN34110082, 18SFRN34110082)
John S LaDue Memorial Fellowship
Career Award for Medical Scientists from the Burroughs Wellcome Fund
The Fredman Fellowship for Aortic DiseaseThe Toomey Fund for Aortic Dissection Research
Article History
Received: 11 May 2020
Accepted: 30 September 2021
First Online: 26 November 2021
Change Date: 10 December 2021
Change Type: Update
Change Details: In the version of this article initially published online, the link for Supplementary Tables 1–21 was missing and has been restored as of 10 December 2021.
Competing interests
: J.P.P. and A.G.B. have served as consultants for Maze Therapeutics. A.-D.A. and C.M.S. are employees of Bayer US LLC (a subsidiary of Bayer AG), and may own stock in Bayer AG. D.J. is supported by grants from Genentech, Eisai, EMD Serono, Takeda, Amgen, Celgene, Placon Therapeutics, Syros, Petra Pharma, InventisBio, Infinity Pharmaceuticals and Novartis. D.J. has also received personal fees from Genentech, Eisai, EMD Serono, Ipsen, Syros, Relay Therapeutics, MapKure, Vibliome, Petra Pharma and Novartis. A.A.P. is employed as a Venture Partner at GV; he is also supported by a grant from Bayer AG to the Broad Institute focused on machine learning for clinical trial design. J.E.H. is supported by a grant from Bayer AG focused on machine learning and cardiovascular disease and a research grant from Gilead Sciences. J.E.H. has received research supplies from EcoNugenics. P.B. is supported by grants from Bayer AG and IBM applying machine learning in cardiovascular disease. P.T.E. is supported by a grant from Bayer AG to the Broad Institute focused on the genetics and therapeutics of cardiovascular diseases. P.T.E. has also served on advisory boards or consulted for Bayer AG, Quest Diagnostics, MyoKardia and Novartis. S.A.L. receives sponsored research support from Bristol Myers Squibb/Pfizer, Bayer AG, Boehringer Ingelheim and Fitbit, and has consulted for Bristol Myers Squibb/Pfizer and Bayer AG, and participates in a research collaboration with IBM. The Broad Institute has filed for a patent on an invention from P.T.E., M.E.L. and J.P.P. related to a genetic risk predictor for aortic disease.